Results 1 to 10 of about 592,922 (116)

PSGL-1 is an evolutionarily conserved antiviral restriction factor [PDF]

mBio, 2023
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to ...
Chao Jiang, Miao Mei, Ying Liu, Min Hou, Jun Jiao, Ya Tan, Xu Tan   +6 more
doaj   +2 more sources

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication [PDF]

mBio
The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection.
Fei Feng, Jiannan Chen, Rong Li, Yunkai Zhu, Yanlong Ma, Ziqiao Wang, Yuyan Wang, Zhichao Gao, Lulu Yang, Yin Yu, Yanfeng Liu, Yingjie Sun, Ying Liao, Xinxin Huang, Qisheng Zhang, Yongheng Huang, Lin Qiu, Jiayu Wu, Jingxian Zhao, Chao Liu, Qiang Ding, Youhua Xie, Zhenghong Yuan, Yue Hong, Ping Zhang, Jing Sun, Jincun Zhao, Rong Zhang   +27 more
doaj   +2 more sources

Mutagenic Analysis of the HIV Restriction Factor Shiftless [PDF]

Viruses, 2022
The interferon-induced host cell protein shiftless (SFL) was reported to inhibit human immunodeficiency virus (HIV) infection by blocking the –1 programmed ribosomal frameshifting (–1PRF) required for expression of the Gag-Pol polyprotein. However, it is
Niklas Jäger, Shreya Ahana Ayyub, Natalia Korniy, Frank Peske, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +6 more
doaj   +2 more sources

Discovery of a Novel Antiviral Effect of the Restriction Factor SPOC1 against Human Cytomegalovirus [PDF]

Viruses
The chromatin-remodeler SPOC1 (PHF13) is a transcriptional co-regulator and has been identified as a restriction factor against various viruses, including human cytomegalovirus (HCMV).
Anna K. Kuderna, Anna Reichel, Julia Tillmanns, Maja Class, Myriam Scherer, Thomas Stamminger   +5 more
doaj   +2 more sources

A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements

Frontiers in Immunology, 2023
The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from ...
Justine Lagisquet, Marcus Conrad, Sabine Wittmann, Bianca Volkmann, Hannah Weissinger, Heinrich Sticht, Thomas Gramberg   +6 more
doaj   +1 more source

MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

mBio, 2023
The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity.
Robert Lodge, Zaikun Xu, Mckenna Eklund, Christina Stürzel, Frank Kirchhoff, Michel J. Tremblay, Tom C. Hobman, Éric A. Cohen   +7 more
doaj   +1 more source

Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses

Viruses, 2021
The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific ...
Amit Gaba, Ben Flath, Linda Chelico
doaj   +1 more source

Vpu and BST2: still not there yet?

Frontiers in Microbiology, 2012
Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV-1 replication and are widely accepted as ‘restriction factors’.
Kei eSato, Peter eGee, Yoshio eKoyanagi, Yoshio eKoyanagi   +3 more
doaj   +1 more source

Structural basis for the antiviral activity of BST-2/tetherin and its viral antagonism

Frontiers in Microbiology, 2011
The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. eArias, Yukie eIwabu, Kenzo eTokunaga   +2 more
doaj   +1 more source

Structural Insights into APOBEC3-Mediated Lentiviral Restriction

Viruses, 2020
Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of ...
Krista A. Delviks-Frankenberry, Belete A. Desimmie, Vinay K. Pathak   +2 more
doaj   +1 more source