Results 41 to 50 of about 5,014,214 (288)

SnapShot: Antiviral Restriction Factors

Cell, 2015
Restriction factors are cellular proteins that inhibit viruses at different steps of their replication cycle and represent an important first line of defense against viral pathogens. This SnapShot provides an overview of cell-intrinsic antiviral factors, describes their properties, and illustrates the striking variety of antiviral mechanisms as well ...
Silvia F. Kluge, Daniel Sauter, Frank Kirchhoff   +2 more
openaire   +2 more sources

Interferon, restriction factors and SUMO pathways

Cytokine & Growth Factor Reviews, 2020
SUMOylation is a reversible post-translational modification that regulates several cellular processes including protein stability, subcellular localization, protein-protein interactions and plays a key role in the interferon (IFN) pathway and antiviral defense.
El-Asmi, Faten, Mcmanus, Francis P., Thibault, Pierre, Chelbi-Alix, Mounira K   +3 more
openaire   +2 more sources

Human Mannose Receptor 1 Attenuates HIV-1 Infectivity in a Virus Isolate-Specific Manner

Viruses, 2023
Human mannose receptor 1 (hMRC1) is a transmembrane glycoprotein that belongs to the C-type lectin family and is expressed on the surface of most tissue macrophages.
Hideki Saito, Sayaka Sukegawa, Sandra Kao, Klaus Strebel   +3 more
doaj   +1 more source

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction

Journal of Virology
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its ...
Pak-Hin Hinson Cheung, Hua Yang, Li Wu
doaj   +1 more source

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

mBio, 2023
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König   +7 more
doaj   +1 more source

The Restriction Factors of Human Immunodeficiency Virus [PDF]

Journal of Biological Chemistry, 2012
Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by ...
Reuben S, Harris, Judd F, Hultquist, David T, Evans   +2 more
openaire   +2 more sources

ASCT2 inhibits HIV-1 infectivity by promoting the incorporation of a gp160/ASCT2 complex into virions

mBio
Restriction factors are type I interferon (IFN)-inducible proteins that provide an early line of defense against HIV-1. Our current findings propose the amino acid transporter ASCT2 as a new host plasma membrane transporter that restricts the infectivity
Luciana Morellatto Ruggieri, Eri Miyagi, Sandra Kao, Hideki Saito, Aymé Drake Figueredo, Haruki Kitamura, María I. Colombo, Klaus Strebel   +7 more
doaj   +1 more source

Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1

Viruses, 2015
Promyelocytic leukemia nuclear bodies, also termed nuclear domain 10 (ND10), have emerged as nuclear protein accumulations mediating an intrinsic cellular defense against viral infections via chromatin-based mechanisms, however, their contribution to the
Nadine Wagenknecht, Nina Reuter, Myriam Scherer, Anna Reichel, Regina Müller, Thomas Stamminger   +5 more
doaj   +1 more source

Schlafens Can Put Viruses to Sleep

Viruses, 2022
The Schlafen gene family encodes for proteins involved in various biological tasks, including cell proliferation, differentiation, and T cell development. Schlafens were initially discovered in mice, and have been studied in the context of cancer biology,
Eui Tae Kim, Matthew D. Weitzman
doaj   +1 more source

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Microbiology Spectrum, 2023
Mice are refractory to infection with human-tropic hepatitis C virus (HCV), although distantly related rodent hepaciviruses (RHV) circulate in wild rodents.
Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, Thomas Pietschmann   +9 more
doaj   +1 more source