The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin [PDF]
, 2010 Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu ...
Wilson, Sam J. +48 more
core +1 more source
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
Frontiers in Microbiology, 2014 The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to suppress replication of viruses with a single-stranded DNA intermediate by inducing mutagenesis and functional inactivation of the virus.
Yuqing eFeng +3 more
doaj +1 more source
MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface
eLife, 2020 The type one interferon induced restriction factor Myxovirus resistance B (MxB) restricts HIV-1 nuclear entry evidenced by inhibition of 2-LTR but not linear forms of viral DNA.
Richard J Miles +5 more
doaj +1 more source
On Restricted Nonnegative Matrix Factorization
CoRR, 2016 Full version of an ICALP'16 ...
Dmitry Chistikov 0001 +4 more
openaire +6 more sources
Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis
Viruses, 2020 HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here we review the role of macrophages in HIV infection and describe complex interactions between viral proteins and host defenses in these cells.
Jay Lubow, Kathleen L. Collins
doaj +1 more source
SDM-assist software to design site-directed mutagenesis primers introducing "silent" restriction sites [PDF]
, 2013 BACKGROUND:Over the past decades site-directed mutagenesis (SDM) has become an indispensable tool for biological structure-function studies. In principle, SDM uses modified primer pairs in a PCR reaction to introduce a mutation in a cDNA insert.
Karnik, Abhijit +2 more
core +5 more sources
Cellular Restriction Factors of Feline Immunodeficiency Virus
Viruses, 2011 Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors ...
Carsten Münk, Jörg Zielonka
doaj +1 more source
Restricted heterogeneity of polyclonal rheumatoid factors [PDF]
Arthritis & Rheumatism, 1987 AbstractThe electrophoretic pattern of rheumatoid factor (RF) was investigated in 40 polyclonal sera, by using radiolabeled IgG. Thirty sera specifically bound IgG aggregates, correlating with their RF titer. The binding pattern was monoclonal or oligoclonal.
J P, Bouvet, Y X, Wu, J, Pillot
openaire +2 more sources
Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity
Viruses, 2021 Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells.
William E. Diehl +6 more
doaj +1 more source
APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1
mBio, 2020 Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened here to A3), act
Mollie M. McDonnell +4 more
doaj +1 more source