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Structural Basis of Intermolecular Interactions Between APOBEC3 and HIV-1 Vif [PDF]
VirusesThe human APOBEC3 (A3) family of cytidine deaminases, including A3G, A3F, and A3H, participates in cellular anti-retroviral immunity. In contrast, to antagonize the anti-retroviral activities of these A3 family proteins, HIV-1 produces its gene product ...
Hirotaka Ode, Yasumasa Iwatani
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The structural mechanism of HIV-2 Vif antagonism of human APOBEC3H [PDF]
Nature CommunicationsHuman APOBEC3 (A3) proteins restrict retrovirus infection by inducing hypermutations in viral cDNA. To counteract this restriction, lentiviruses, such as HIV-1 and HIV-2 encode the viral infectivity factor (Vif), which hijacks a host Cullin-RING E3 ...
Yange Niu +5 more
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Engineering Proceedings, 2022 As the main functional element of the fuel cell, the bipolar plate ensures the functions of media distribution, electron conduction, and mechanical stability of the entire fuel cell stack.
Maik Fiedler +2 more
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Ciencia y Agricultura, 2023 Los virus de la leucemia felina (ViLeF) y de la inmunodeficiencia felina (VIF) pertenecen a la familia de retrovirus que afectan a todos los gatos del mundo, incluyendo algunos felinos salvajes.
Cristian Daniel Nausa-Acosta +1 more
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Scientific Annals of Economics and Business, 2022 This paper estimates NIFTY index from Indian stock market by considering a cluster of MSCI European, Middle East and Asian stock market indices. In the forecasting process, we obtain group of independent variables to test its relative impact over ...
Jatin Trivedi +4 more
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Insights into the dual activity of SIVmac239 Vif against human and African green monkey APOBEC3G. [PDF]
PLoS ONE, 2012 Human immunodeficiency virus type 1 (HIV-1) Vif is essential for viral evasion of the host antiviral protein APOBEC3G (APO3G). The Vif protein from a distantly related African green monkey (Agm) simian immunodeficiency virus (SIVagm) is unable to ...
Ritu Gaur, Klaus Strebel
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Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFβ and CRL5 E3 ubiquitin ligase components. [PDF]
PLoS ONE, 2012 Human immunodeficiency virus-1 (HIV-1) viral infectivity factor (Vif) is essential for viral replication because of its ability to eliminate the host's antiviral response to HIV-1 that is mediated by the APOBEC3 family of cellular cytidine deaminases ...
Xiaohong Zhou +4 more
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Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
Pharmaceuticals, 2020 Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used ...
Alexej Dick, Simon Cocklin
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Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. [PDF]
PLoS Pathogens, 2005 The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the
Viviana Simon +5 more
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Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
Nature Communications, 2023 Great effort has been devoted to discovering the basis of A3G-Vif interaction, the key event of HIV’s counteraction mechanism to evade antiviral innate immune response.
Takahide Kouno +6 more
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