Results 21 to 30 of about 79,692 (216)
Identification of HIV-1 Vif regions required for CBF-β interaction and APOBEC3 suppression.
PLoS ONE, 2014 Human immunodeficiency virus type 1 (HIV-1) Vif requires core binding factor β (CBF-β) to degrade the host APOBEC3 restriction factors. Although a minimum domain and certain amino acids of HIV-1 Vif, including hydrophobic residues at the N-terminal, have
Hong Wang +5 more
doaj +1 more source
Retrovirology, 2007 Background The HIV-1 accessory protein known as viral infectivity factor or Vif binds to the host defence factor human APOBEC3G (hA3G) and prevents its assembly with viral particles and mediates its elimination through ubiquitination and degradation by ...
Presnyak Vlad +2 more
doaj +1 more source
The resistance of human APOBEC3H to HIV-1 NL4-3 molecular clone is determined by a single amino acid in Vif. [PDF]
PLoS ONE, 2013 Some human APOBEC3 cytidine deaminases have antiviral activity against HIV-1 and other retroviruses. The single deaminase domain APOBEC3H (A3H) enzyme is highly polymorphic and multiple A3H haplotypes have been identified.
Marcel Ooms +3 more
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Evolutionary Conservation of PP2A Antagonism and G2/M Cell Cycle Arrest in Maedi-Visna Virus Vif
Viruses, 2022 The canonical function of lentiviral Vif proteins is to counteract the mutagenic potential of APOBEC3 antiviral restriction factors. However, recent studies have discovered that Vif proteins from diverse HIV-1 and simian immunodeficiency virus (SIV ...
Adeline M. Luperchio +2 more
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Virology Journal, 2011 The two major cytopathic factors in human immunodeficiency virus type 1 (HIV-1), the accessory proteins viral infectivity factor (Vif) and viral protein R (Vpr), inhibit cell-cycle progression at the G2 phase of the cell cycle.
Chaigne-Delalande Benjamin +4 more
doaj +1 more source
Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface
Cell Reports, 2015 Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation.
Michael Letko +4 more
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Вопросы вирусологииIntroduction. The Vif protein counteracts cellular deaminases, APOBEC3, which prevent viral replication. Vif is used for development of therapeutic agents.
Anastasiia A. Antonova +8 more
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Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
HIV Vif protein in docetaxel treatment of breast cancer cells
Annals of Medicine, 2021 Introduction Breast cancer is one of the most frequently diagnosed cancers in the world and is also the leading cause of death in women diagnosed with this disease. Recently, APOBEC3 proteins have been identified as potent mutagenic agents of genomic DNA
Pedro Cipriano +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk +10 more
wiley +1 more source