Results 11 to 20 of about 79,692 (216)

APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

mBio, 2023
HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+ T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) family of proteins (at least ...
Terumasa Ikeda, Ryo Shimizu, Hesham Nasser, Michael A. Carpenter, Adam Z. Cheng, William L. Brown, Daniel Sauter, Reuben S. Harris   +7 more
doaj   +1 more source

Application of the Wave Based Technique for steady-state semi-infinite sound radiation analysis

Computer Assisted Methods in Engineering and Science, 2022
This paper reports on the development of a novel wave based prediction technique for the steady-state sound radiation analysis of three-dimensional semi-infinite problems.
Jan Rejlek, Achim Hepberger, Hans-Herwig Priebsch, Bert Pluymers, Wim Desmet   +4 more
doaj  

Expression Level of HIV-1 Vif Can Be Fluctuated by Natural Nucleotide Variations in the vif-Coding and Regulatory SA1D2prox Sequences of the Proviral Genome

Frontiers in Microbiology, 2019
Vif is required for HIV-1 replication in natural target cells by counteracting host restriction factors, APOBEC3 (A3) proteins. We recently demonstrated that Vif expression level can be changed by naturally occurring single-nucleotide variations within ...
Naoya Doi, Takaaki Koma, Akio Adachi, Masako Nomaguchi   +3 more
doaj   +1 more source

The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process

Viruses, 2021
HIV-1 Vif plays an essential role in viral replication by antagonizing anti-viral cellular restriction factors, a family of APOBEC3 proteins. We have previously shown that naturally-occurring single-nucleotide mutations in the SA1D2prox region, which ...
Takaaki Koma, Naoya Doi, Mai Takemoto, Kyosuke Watanabe, Hideki Yamamoto, Satoshi Nakashima, Akio Adachi, Masako Nomaguchi   +7 more
doaj   +1 more source

Use of YouTube for diffusion of innovative agricultural technologies: A digital self-help approach to the farmers [PDF]

Journal of Agricultural Sciences (Belgrade)
The diffusion of innovative agricultural technologies is essential for improving productivity, food security, and rural livelihoods in developing countries, where conventional extension services often face financial and institutional constraints.
Mazumder Mohummed Shofi Ullah, Wadud Fatema, Barua Sushama   +2 more
doaj   +1 more source

Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H

Nature Communications, 2023
Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity factor (Vif) to target specific human A3s for proteasomal degradation.
Fumiaki Ito, Ana L. Alvarez-Cabrera, Kyumin Kim, Z. Hong Zhou, Xiaojiang S. Chen   +4 more
doaj   +1 more source

Comparison of fast regression algorithms in large datasets

Kuwait Journal of Science, 2023
The aim is to compare the performances of fast regression methods, namely dimensional reduction of correlation matrix (DRCM), nonparametric dimensional reduction of correlation matrix (N-DRCM), variance inflation factor (VIF) regression, and robust VIF (
Sengul Cangur, Handan Ankarali
doaj   +1 more source

Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells

Retrovirology, 2004
Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of APOBEC3G encapsidation is paralleled by a reduction of its intracellular
Goila-Gaur Ritu, Opi Sandrine, Takeuchi Hiroaki, Khan Mohammad A, Miyagi Eri, Kao Sandra, Strebel Klaus   +6 more
doaj   +1 more source

MDM2 is a novel E3 ligase for HIV-1 Vif

Retrovirology, 2009
The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G).
Tomonaga Mitsunori, Sato Toshihiro, Kondoh Hiroshi, Iwai Kazuhiro, Matsui Masashi, Io Katsuhiro, Itoh Katsuhiko, Higashitsuji Hiroaki, Shirakawa Kotaro, Takaori-Kondo Akifumi, Izumi Taisuke, Ikeda Satoru, Akari Hirofumi, Koyanagi Yoshio, Fujita Jun, Uchiyama Takashi   +15 more
doaj   +1 more source

Aromatic disulfides as potential inhibitors against interaction between deaminase APOBEC3G and HIV infectivity factor

Acta Biochimica et Biophysica Sinica, 2022
APOBEC3G (A3G) is a member of cytosine deaminase family with a variety of innate immune functions. It displays activities against retrovirus and retrotransposon by inhibition of virus infectivity factor (Vif)-deficient HIV-1 replication.
Yan Xiaoxuan, Chen Chao, Wang Chunxi, Lan Wenxian, Wang Jianguo, Cao Chunyang   +5 more
doaj   +1 more source