Results 1 to 10 of about 5,637 (158)

APOBEC3 Mediates Resistance to Oncolytic Viral Therapy [PDF]

Molecular Therapy - Oncolytics, 2018
Tumor cells frequently evade applied therapies through the accumulation of genomic mutations and rapid evolution. In the case of oncolytic virotherapy, understanding the mechanisms by which cancer cells develop resistance to infection and lysis is ...
Amy M Molan, Alan Melcher, Kevin G Shim
exaly   +4 more sources

Mouse APOBEC3 Restriction of Retroviruses

Viruses, 2020
Apolipoprotein B mRNA editing enzyme, catalytic peptide 3 (APOBEC3) proteins are critical host proteins that counteract and prevent the replication of retroviruses.
Susan R. Ross, Karen Salas-Briceno
exaly   +4 more sources

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present

Viruses, 2021
The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Jumpei Ito, Kei Sato, Keiya Uriu
exaly   +3 more sources

Genomic Epidemiology and Clinical Characteristics of Mpox Lineage C.1 Outbreak in Thailand, 2023-2024. [PDF]

J Med Virol
ABSTRACT Since 2022, human monkeypox virus (hMPXV) has emerged in non‐endemic regions, including Thailand. However, the genomic dynamics and clinical correlates of local transmission remain incompletely defined. Whole‐genome sequencing was performed on hMPXV from 16 patients in Thailand (2023–2024) using targeted amplicon NGS.
Suwannakarn K, Chaimayo C, Boonmee A, Leeyaphan C, Jirawattanadon P, Athiprayoon P, Saengdao N, Taiphakphaibun P, Deetippasert C, Nuwong W, Athipanyasilp N, Pattama A, Horthongkham N.   +12 more
europepmc   +2 more sources

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B [PDF]

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +2 more sources

Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis [PDF]

Genome Biology
APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection.
Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel DeWeerd, Abby M. Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi   +12 more
doaj   +2 more sources

Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions [PDF]

Frontiers in Immunology
The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family was first defined as an innate antiviral defense system, but the APOBEC3 subfamily (APOBEC3s) is now recognized as a major endogenous source of somatic mutagenesis in cancer ...
Qiaoxi Li, Qiaoxi Li, Wenyu Wan, Wenyu Wan, Zihan Zhu, Zihan Zhu, Xuanduo Lin, Xuanduo Lin, Fei Wang, Fei Wang, Mengmeng Li, Mengmeng Li, Hao Guo, Hao Guo, Yang Yang, Yang Yang   +15 more
doaj   +2 more sources

APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling [PDF]

Nature Communications
The APOBEC3 family of RNA and single stranded DNA cytidine deaminases contribute prominently to the mutagenesis of certain cancers including urothelial carcinoma of the bladder (UC).
Michael S. Sturdivant, Andrew S. Truong, Mi Zhou, Elliott D. Toomer, Wolfgang Beckabir, John Raupp, Ujjawal Manocha, Ibardo A. Zambrano, Hung-Jui Tan, Marc A. Bjurlin, Angela B. Smith, Tracy L. Rose, Matthew I. Milowsky, Sara E. Wobker, Kathryn H. Gessner, Jeffrey S. Damrauer, William Y. Kim   +16 more
doaj   +2 more sources

Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif

Viruses, 2013
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways.
Valgerdur Andrésdóttir
exaly   +3 more sources

APOBEC3 Interference during Replication of Viral Genomes

Viruses, 2015
Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of
Luc Willems, Nicolas A. Gillet
exaly   +3 more sources