Results 31 to 40 of about 5,637 (158)
Effect of Vif in doxorubicin treated breast cancer cells
Annals of Medicine, 2021 Introduction Several studies linked DNA cytosine deaminase APOBEC3 to mutational process driving carcinogenesis [1]. However, APOBEC3 expression varies in breast cancer cells [2] and their role in breast cancer treatment remains elusive.
Susana Bandarra +4 more
doaj +1 more source
Mouse strain-specific splicing of Apobec3
, 2006 Host resolution of viral infection is dependent upon components of the innate and acquired immune system. The mammalian protein Apobec3 plays an important role as part of the immune system’s innate defenses through its modification of reverse ...
Casey, Ryan Edward
core +3 more sources
Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?
Viruses, 2018 The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified.
Zeli Zhang +6 more
doaj +1 more source
Insights into the motif preference of APOBEC3 enzymes. [PDF]
PLoS ONE, 2014 We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT.
Diako Ebrahimi +2 more
doaj +1 more source
Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles
Nature Communications, 2023 Antiretroviral APOBEC3 may contribute to HIV-1 latency. In this study, Ajoge and Renner et al. identify a previously undescribed function of human APOBEC3 proteins in redirecting integrations of HIV-1 DNA into more transcriptionally inactive regions of ...
Hannah O. Ajoge +10 more
doaj +1 more source
Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance
Heliyon, 2019 The APOBEC3 enzymes can induce mutagenesis of HIV-1 proviral DNA through the deamination of cytosine. HIV-1 overcomes this restriction through the viral protein Vif that induces APOBEC3 proteasomal degradation.
Nazanin Mohammadzadeh +5 more
doaj +1 more source
APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model. [PDF]
PLoS Pathogens, 2014 Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral ...
Kei Sato +13 more
doaj +1 more source
Heliyon, 2022 Background: Kidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of renal cell cancer. APOBEC3 activity has been identified in a variety of human cancers.
Ting Peng +9 more
doaj +1 more source
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source
Beilstein Journal of Organic ChemistryNucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the quick ...
Maksim V. Kvach +5 more
doaj +1 more source