Results 1 to 10 of about 432 (87)

APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma

Viruses, 2021
APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes.
Daniel L Faden, Lisa Mirabello
exaly   +3 more sources

APOBECs and Herpesviruses

Viruses, 2021
The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections.
Adam Z. Cheng, Sofia N. Moraes, Nadine M. Shaban, Elisa Fanunza, Craig J. Bierle, Peter J. Southern, Wade A. Bresnahan, Stephen A. Rice, Reuben S. Harris   +8 more
doaj   +1 more source

SARS-CoV-2 variants： origin， drivers and prevention measures

Shanghai yufang yixue, 2022
COVID-19 has emerged around the world since December 2019 and rapidly evolves as a major global public health challenge. SARS-CoV-2 is a positive single-stranded RNA virus with a relatively high natural mutation rate. The emergence of SARS-CoV-2 variants
SHEN Jiaying, LIN Jiansheng, CAO Guangwen   +2 more
doaj   +1 more source

APOBEC3 as a driver of genetic intratumor heterogeneity

Molecular & Cellular Oncology, 2021
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor
Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F. Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton   +6 more
doaj   +1 more source

Constructing an APOBEC-related gene signature with predictive value in the overall survival and therapeutic sensitivity in lung adenocarcinoma

Heliyon, 2023
Background: APOBEC family play an important role in cancer mutagenesis and tumor development. The role of APOBEC family in lung adenocarcinoma (LUAD) has not been studied comprehensively.
Yu Luo, Huiru Wang, Jian Zhong, Jianrong Shi, Xianlin Zhang, Yanni Yang, Ruixin Wu   +6 more
doaj   +1 more source

Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus

Molecular Therapy: Nucleic Acids, 2023
APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA ...
Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Natalia Ponomareva, Ekaterina Bayurova, Natalia Zakirova, Alla Kondrashova, Irina Goptar, Anastasiya Nikiforova, Anna Sudina, Yurii Babin, Ilya Gordeychuk, Alexander Lukashev, Andrey A. Zamyatnin, Jr., Alexander Ivanov, Vladimir Chulanov   +15 more
doaj   +1 more source

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

Genome Medicine, 2020
Background APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only
Ming-Jun Shi, Xiang-Yu Meng, Jacqueline Fontugne, Chun-Long Chen, François Radvanyi, Isabelle Bernard-Pierrot   +5 more
doaj   +1 more source

APOBEC-1 deletion enhances cisplatin-induced acute kidney injury

Scientific Reports, 2023
Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo regulated necrosis. Repair is almost complete after a single dose. We now demonstrate a role for Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec-1 ...
Xiaojia Guo, Valerie Blanc, Nicholas O. Davidson, Heino Velazquez, Tian-min Chen, Dennis G. Moledina, Gilbert W. Moeckel, Robert L. Safirstein, Gary V. Desir   +8 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer

Frontiers in Oncology, 2022
IntroductionTumor mutational burden (TMB) and APOBEC mutational signatures are potential prognostic markers in patients with advanced urothelial carcinoma (aUC).
Divya Natesan, Li Zhang, Henry J. Martell, Tanya Jindal, Patrick Devine, Bradley Stohr, Carlos Espinosa-Mendez, James Grenert, Jessica Van Ziffle, Nancy Joseph, Sarah Umetsu, Courtney Onodera, Michelle Turski, Emily Chan, Arpita Desai, Rahul Aggarwal, Anthony Wong, Sima Porten, Jonathan Chou, Terence Friedlander, Lawrence Fong, Eric J. Small, Alejandro Sweet-Cordero, Vadim S. Koshkin   +23 more
doaj   +1 more source