Results 31 to 40 of about 10,630 (206)

APOBEC‐1‐mediated RNA editing [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractRNA editing defines a molecular process by which a nucleotide sequence is modified in the RNA transcript and results in an amino acid change in the recoded message from that specified in the gene. We will restrict our attention to the type of RNA editing peculiar to mammals, i.e., nuclear C to U RNA editing.
Valerie, Blanc, Nicholas O, Davidson
openaire   +2 more sources

jt-lanl/cov-voc: covid+monkepox+apobec

, 2022
In addition to routines for characterizing covid variants of concern, this release includes apobec analysis code useful for monkeypox ...
James Theiler
core   +1 more source

Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and watanabe heritable hyperlipidemic rabbits

Journal of Lipid Research, 1996
Apolipoprotein (apo) B exists in two forms, the full length protein apoB-100 and the carboxyterminal-truncated apoB-48 that is synthesized in the intestine due to editing of the apoB mRNA which generates a premature stop codon.
J Greeve, V K Jona, N R Chowdhury, M S Horwitz, J R Chowdhury   +4 more
doaj   +1 more source

APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution [PDF]

, 2018
The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade.
Kanu, N, Bartek, J, Harris, RS, Venkatesan, S, Hare, J, Rosenthal, R, Swanton, C, McGranahan, N, Quezada, SA   +8 more
core   +2 more sources

Hepatic secretion of small lipoprotein particles in apobec-1−/− mice is regulated by the LDL receptor

Journal of Lipid Research, 2004
Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches.
Fatiha Nassir, Yan Xie, Bruce W. Patterson, Jianyang Luo, Nicholas O. Davidson   +4 more
doaj   +1 more source

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

, 2021
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for
J Bartek (11283483), RS Harris (11283489), N McGranahan (7756325), SA Quezada (9158285), S Venkatesan (9894704), C Swanton (7756520), R Rosenthal (7756343), N Kanu (8842280), J Hare (11283486)   +8 more
core   +1 more source

Restriction of Foamy Viruses by APOBEC Cytidine Deaminases [PDF]

Journal of Virology, 2006
ABSTRACT Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV.
Delebecque, Frédéric, Suspene, Rodolphe, Calattini, Sara, Casartelli, Nicoletta, Saib, Ali, Froment, Alain, Wain-Hobson, Simon, Gessain, Antoine, Vartanian, Jean Pierre, Schwartz, Olivier   +9 more
openaire   +4 more sources

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy

OncoImmunology, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Amélie Boichard, Timothy V. Pham, Huwate Yeerna, Aaron Goodman, Pablo Tamayo, Scott Lippman, Garrett M. Frampton, Igor F. Tsigelny, Razelle Kurzrock   +8 more
doaj   +1 more source

The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques. [PDF]

PLoS ONE, 2012
The AID/APOBEC family (activation induced deaminase/apolipoprotein B mRNA editing cytokine deaminase) in B cells play important roles in adaptive and innate immunity.
Yufei Wang, Trevor Whittall, Durdana Rahman, Evelien M Bunnik, Robert Vaughan, Jørgen Schøller, Lesley A Bergmeier, David Montefiori, Mahavir Singh, Hanneke Schuitemaker, Thomas Lehner   +10 more
doaj   +1 more source

Switching APOBEC mutation signatures [PDF]

Nature Reviews Genetics, 2019
Two studies report substantial temporal and spatial variability in mutagenic signatures caused by APOBEC cytidine deaminases in cancer.
openaire   +2 more sources