Results 41 to 50 of about 10,630 (206)

Molecular origins of APOBEC-associated mutations in cancer [PDF]

DNA Repair, 2020
The APOBEC family of cytidine deaminases has been proposed to represent a major enzymatic source of mutations in cancer. Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. We also highlight newly identified human cell models of APOBEC mutagenesis, including cancer cell lines with suspected endogenous APOBEC ...
Mia Petljak, John Maciejowski
openaire   +2 more sources

A PRESPECTIVE STUDY ON APOBEC PROTEIN FAMILY [PDF]

, 2019
Apobec is an apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like" is a family of deaminases. It has two types of APOBEC enzymes n-terminal of apobec enzyme and C-terminal of APOBEC enzyme.
KOMAL, S., GEJALAKSHMI, S., HARIKRISHNAN, N.   +2 more
core   +1 more source

Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families

Frontiers in Bioscience-Landmark
RNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov, Anton Buzdin, Maria Suntsova   +2 more
doaj   +1 more source

Characterization of SARS-CoV-2 Mutational Signatures from 1.5+ Million Raw Sequencing Samples

Viruses, 2022
We present a large-scale analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) substitutions, considering 1,585,456 high-quality raw sequencing samples, aimed at investigating the existence and quantifying the effect of mutational ...
Andrea Aroldi, Fabrizio Angaroni, Deborah D’Aliberti, Silvia Spinelli, Ilaria Crespiatico, Valentina Crippa, Rocco Piazza, Alex Graudenzi, Daniele Ramazzotti   +8 more
doaj   +1 more source

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

, 2023
Introduction APOBEC mutational signatures are one of the most important mutational signatures in newly diagnosed multiple myeloma (NDMM). APOBEC mutagenesis primarily works through two enzymes, APOBEC3A (A3A) and APOBEC3B (A3B).
Papadimitriou, Marios, Meads, Mark B, Weinhold, Niels, Usmani, Saad Z, Landgren, Ola, Ziccheddu, Bachisio, Maura, Francesco, Poos, Alexandra Maria, Raab, Marc S., Maclachlan, Kylee H, Morgan, Gareth J., Tauro, Marilena, Landgren, Carl, Alaoui, Abdessamad Youssfi, Shain, Kenneth H.   +14 more
core   +1 more source

APOBEC Mutagenesis as a Driver of Tumor Evolution through Genetic Heterogeneity and Immunogenicity

, 2021
The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidine deaminases is one of the most common endogenous sources of single base substitution mutations in human cancer.
DiMarco, Ashley
core   +1 more source

Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide

Journal of Lipid Research, 1997
In humans, both the expression of apobec-1 and the C to U deamination of apoB mRNA are confined to the small intestine. In order to understand the tissue-restricted pattern of apobec-1 expression, we have isolated the chromosomal gene spanning the human ...
K Hirano, J Min, T Funahashi, D A Baunoch, N O Davidson   +4 more
doaj   +1 more source

The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system

, 2006
Activation-induced cytidine deaminase (AID) is indispensable for immunoglobulin maturation by somatic hypermutations and class switch recombination and is supposed to deaminate cytidines in DNA, while its homolog APOBEC-1 edits apolipoprotein (apo) B ...
Krause, Kristina, Marcu, Kenneth B, Greeve, Jobst   +2 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]

Annals of Mechnikov's Institute, 2019
Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).
Kolotova T. , Makarenko V., Sorokoumova L., Davidenko M.   +3 more
doaj   +3 more sources