APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma [PDF]
Viruses, 2021 APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes.
Daniel L Faden, Lisa Mirabello
exaly +4 more sources
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors. [PDF]
Cell Reports, 2019 Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using ...
Stephen M. Hewitt +2 more
exaly +4 more sources
Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer [PDF]
Frontiers in ImmunologyBackgroundAPOBEC cytidine deaminases generate characteristic TCW-context mutations that diversify cancer genomes, yet their functional impact on colorectal cancer (CRC) progression and the tumor microenvironment (TME) remains poorly defined.MethodsWe ...
Junting Chen +4 more
doaj +2 more sources
OncoImmunology, 2019 Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Amélie Boichard, Garrett M Frampton
exaly +2 more sources
Heliyon, 2023 Background: APOBEC family play an important role in cancer mutagenesis and tumor development. The role of APOBEC family in lung adenocarcinoma (LUAD) has not been studied comprehensively.
Yanni Yang
exaly +3 more sources
Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions [PDF]
Frontiers in ImmunologyThe apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family was first defined as an innate antiviral defense system, but the APOBEC3 subfamily (APOBEC3s) is now recognized as a major endogenous source of somatic mutagenesis in cancer ...
Qiaoxi Li +15 more
doaj +2 more sources
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas [PDF]
Annals of Oncology, 2022 M F Berger, X Pei, P Selenica
exaly +2 more sources
MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing [PDF]
Journal of VirologyThe 2022 outbreak of monkeypox virus (MPXV), a double-stranded DNA virus, is remarkable for an unusually high number of single-nucleotide substitutions compared to earlier strains, with a strong bias toward C→T and G→A transitions consistent with the ...
Alisa O. Lyskova +13 more
doaj +2 more sources
APOBEC mutagenesis is low in most types of non-B DNA structures [PDF]
IScience, 2022 Marat D. Kazanov +2 more
exaly +2 more sources
Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis [PDF]
Genome BiologyAPOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection.
Márton Miskei +12 more
doaj +2 more sources