Results 21 to 30 of about 93,358 (167)

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer

European Urology, 2019
International audienceFGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC→TGC), represents an APOBEC-type motif and is ...
Lamy, Philippe, Banday, A. Rouf, Dyrskjøt, Lars, Meng, Xiang-Yu, Chen, Chun-Long, Bernard-Pierrot, Isabelle, Yang, Jie, Radvanyi, François, Moreno-Vega, Aura, Shi, Ming-Jun, Prokunina-Olsson, Ludmila   +10 more
core   +7 more sources

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions [PDF]

Cell Reports, 2015
An antiviral component of the human innate immune system—the APOBEC cytidine deaminases—was recently identified as a prominent source of mutations in cancers.
Marat D. Kazanov, Steven A. Roberts, Paz Polak, John Stamatoyannopoulos, Leszek J. Klimczak, Dmitry A. Gordenin, Shamil R. Sunyaev   +6 more
doaj   +2 more sources

APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses. [PDF]

Cancer Immunol Res, 2022
The APOBEC family of cytidine deaminases is one of the most common endogenous sources of mutations in human cancer. Genomic studies of tumors have found that APOBEC mutational signatures are enriched in theHER2 subtype of breast cancer and are associated
DiMarco AV, Qin X, McKinney BJ, Garcia NMG, Van Alsten SC, Mendes EA, Force J, Hanks BA, Troester MA, Owzar K, Xie J, Alvarez JV.   +11 more
europepmc   +2 more sources

Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries [PDF]

Biological Procedures Online
Background The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family plays a vital mutagenic role in diverse human malignancies.
Wei Luo, Feng Liu, Mengyu Li, Jialong Yu, Ziyun Liu, Xuan Cheng, Yue Huang, Yu Liu, Mei Tao, Yuqi Wang, Yiping Zou, Xiaobin Shang, Chao Yang, Xianhui Ruan, Yanchao Qin, Xiangqian Zheng   +15 more
doaj   +2 more sources

Characterizing Somatic Mutation Clusters in Cancers Enriched with APOBEC Mutagenesis [PDF]

The APOBEC family of cytidine deaminases plays an active role in the human immune system, combating viruses and transposable elements. These enzymes convert cytosine to uracil, which often leads to C->T or C->G mutations within the specific nucleotide
Kazanov, Fedor, Ponomarev, Gennady, Kazanov, Marat   +2 more
core   +1 more source

Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer [PDF]

Molecular Cancer
Background Luminal breast cancer is rising rapidly among East Asian women, particularly younger patients, with variable clinical outcome, yet current risk-stratification models inadequately predict early recurrence of under-studied young-onset cases.
Ya-Hsuan Chang, Yi-Ju Chen, Zhi-Jie Hong, Yi-Jing Hsiao, Kuen-Tyng Lin, Guo-Shiou Liao, Sheng-Fang Su, Ze-Shiang Lin, Huei-Wen Chen, Chia-Li Han, Eric Sheng-Wen Chen, Yin-Chen Hsu, Yan-Ming Chen, Hao Fang, Hao-Chin Yang, Yan-Si Chen, Chien-Yu Lin, Hsiang-En Hsu, Ching-Hung Lin, Pin-Lian Jiang, Pei-Shan Wu, Ching-Wen Chen, Chen-Ting Hung, Ethan Wu, Wei-Tzu Chiu, Fan-Ni Hsing, Tsai-Pei Liu, Chia-Yu Wang, Yu-Tai Wang, Chang-Wei Yeh, Ki-Hok Liao, Ana I Robles, Henry Rodriguez, Show-Ling Yang, Mien-Chie Hung, Yen-Shen Lu, Hsuan-Yu Chen, Sung-Liang Yu, Jyh-Cherng Yu, Yu-Ju Chen   +39 more
doaj   +2 more sources

Replication Stress Induces Hyper-Apobec Mutagenesis in Multiple Myeloma

Blood
Introduction APOBEC mutational signatures are prominent in newly diagnosed multiple myeloma (NDMM), driven primarily by the enzymes APOBEC3A (A3A) and APOBEC3B (A3B). The activity of these enzymes varies significantly among patients, with some exhibiting
Papadimitriou, Marios, Weinhold, Niels, Panahi, Afsaneh, Landgren, Ola, Ziccheddu, Bachisio, Usmani, Saad Z., Kuchenbauer, Florian, Maura, Francesco, Poos, Alexandra Maria, Meads, Mark B., Morgan, Gareth, Raab, Marc S., Maclachlan, Kylee H, Tauro, Marilena, Landgren, Carl, Alaoui, Abdessamad Youssfi, Magaletti, Dario, Shain, Kenneth H.   +17 more
core   +2 more sources

Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns [PDF]

International Journal of Oral Science
Tobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC).
Sophie Deneuve, Béatrice Fervers, Julia S. Bruno, Emma Bach, Sergey Senkin, Gabrielle Goldman-Lévy, Christine Carreira, Israa Laklouk, Rong Hu, Liacine Bouaoun, Olivia Pérol, Bérénice Chavanel, Lingeng Lu, Taja Lozar, Tarik Gheit, Paul F. Lambert, Isabelle Coste, Toufic Renno, Jiri Zavadil, François Virard   +19 more
doaj   +2 more sources

Abstract 598: APOBEC mutagenesis: a link between innate immunity and cancer

Cancer Research, 2017
Introduction: Cytidine deaminase activity of APOBEC3 enzymes generates mutations that restrict viral infection and eliminate tumor cells but also contribute to viral and tumor evolution.
Ludmila Prokunina-Olsson, A Rouf Banday, Krizia-Ivana Udquim, Olusegun O. Onabajo, Adeola Obajemu   +4 more
core   +2 more sources

APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

, 2018
The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade.
Kanu, N, Bartek, J, Harris, RS, Venkatesan, S, Hare, J, Rosenthal, R, Swanton, C, McGranahan, N, Quezada, SA   +8 more
core   +2 more sources