APOBEC Mutagenesis in Cancer Development and Susceptibility [PDF]
CancersAPOBEC cytosine deaminases are prominent mutators in cancer, mediating mutations in over 50% of cancers. APOBEC mutagenesis has been linked to tumor heterogeneity, persistent cell evolution, and therapy responses.
Mia Petljak
exaly +5 more sources
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution [PDF]
Annals of Oncology, 2018 The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade.
Nicholas McGranahan +2 more
exaly +7 more sources
APOBEC mutagenesis is a common process in normal human small intestine. [PDF]
Nat Genet, 2023 APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer types. However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC enzymes responsible.
Wang Y +21 more
europepmc +18 more sources
APOBEC mutagenesis and selection for NFE2L2 contribute to the origin of lung squamous-cell carcinoma [PDF]
Lung Cancer, 2022 Lung squamous-cell carcinoma originates as a consequence of oncogenic molecular variants arising from diverse mutagenic processes such as tobacco, defective homologous recombination, aging, and cytidine deamination by APOBEC proteins. Only some of the many variants generated by these processes actually contribute to tumorigenesis.
Stephen G Gaffney +2 more
exaly +4 more sources
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis [PDF]
Cell, 2019 Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types.
Serena Nik-Zainal +2 more
exaly +8 more sources
Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus
Molecular Therapy: Nucleic Acids, 2023 APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA ...
Dmitry Kostyushev +15 more
doaj +2 more sources
Investigating the regulation of APOBEC mutagenesis in cancer [PDF]
The sequencing of cancer genomes has revealed that cancers harbour recurrent patterns of mutation, known as mutational signatures. One common mutational signature, known as the APOBEC signature, is found in over 70% of cancer types.
core +3 more sources
APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma [PDF]
Oral Oncology, 2019 HNSCC is an immunologically active tumor with high levels of immune cell infiltration, high mutational burden and a subset of patients who respond to immunotherapy. One of the primary sources of mutations in HNSCC is the cytidine deaminase APOBEC3, which is a known participant in innate immunity.
Daniel L Faden, Luc G T Morris
exaly +5 more sources
APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development [PDF]
Cell Reports, 2014 APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over 99%
Stephen Henderson +4 more
doaj +2 more sources
The involvement of hypoxia in APOBEC-mediated mutagenesis in multiple cancers [PDF]
, 2019 Mutational signatures have been studied to associate mutations to their originating causes. One such signature is that of the APOBEC family of proteins.
Liang, Jiachen
core +3 more sources