Results 61 to 70 of about 10,630 (206)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, Volume 20, Issue 10, Page 2410-2423, October 2026.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

APOBEC: A molecular driver in cervical cancer pathogenesis

Cancer Letters, 2021
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus (HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other genetic and epigenetic factors also are involved in the underlying pathogenesis of cervical cancer.
Revathidevi, Sundaramoorthy, Murugan, Avaniyapuram Kannan, Nakaoka, Hirofumi, Inoue, Ituro, Munirajan, Arasambattu Kannan   +4 more
openaire   +2 more sources

RNA Editing Alterations Define Disease Manifestations in the Progression of Experimental Autoimmune Encephalomyelitis (EAE)

Cells, 2022
RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic ...
Dimitra Dafou, Eirini Kanata, Spyros Pettas, Nikolaos Bekas, Athanasios Dimitriadis, Garyfalia Kempapidou, Roza Lagoudaki, Paschalis Theotokis, Olga Touloumi, Nikoleta Delivanoglou, Evangelia Kesidou, Konstantinos Xanthopoulos, Nikolaos Grigoriadis, Fotini Nina Papavasiliou, Theodoros Sklaviadis   +14 more
doaj   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Study of the Genetic Expression of Antiretroviral Restriction Factors and Acute Phase Proteins in Cattle Infected with Bovine Leukemia Virus

Pathogens, 2023
The goal of this study was to analyze the genetic expression of antiretroviral restriction factors (ARF) and acute phase proteins (APP), as well as their correlation with proviral and viral loads in cattle with aleukemic (AL) and persistent lymphocytosis
Ana S. González-Méndez, Jorge L. Tórtora Pérez, Edith Rojas-Anaya, Hugo Ramírez Álvarez   +3 more
doaj   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Are APOBEC deminases oncogenic in HPV infection? [PDF]

, 2017
本研究は遺伝子改編酵素群APOBECのヒトパピローマウイルス(HPV)感染病態における病的役割を明らかにする事を目的とした。その結果、①APOBECはHPVやインターフェロンにより発現が誘導される事、②APOBECはHPVゲノムや宿主ゲノムに変異を導入し、またHPVゲノムの宿主へのインテグレーションと相関する事、③その一方でHPVビリオン産生細胞で発現すると、感染性を低下させる事を発見した。以上の知見は抗ウイルス因子と発癌因子という ...
若江, 亨祥, 78964, 70638303
core   +1 more source

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

, 2013
Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clusters in human tumors.
Michael A Resnick, Gregory V Kryukov, Fargo, David, Gad Getz, Steven A Roberts, Harris, Shawn, Shah, Ruchir R, Saksena, Gordon, Carter, Scott L, Sara A Grimm, Petar Stojanov, Gordenin, Dmitry A, Scott L Carter, Stojanov, Petar, Leszek J Klimczak, Gordon Saksena, Adam Kiezun, Kryukov, Gregory V, David Fargo, Ruchir R Shah, Kiezun, Adam, Resnick, Michael A, Klimczak, Leszek J, Shawn Harris, Michael S Lawrence, Lawrence, Michael S, Getz, Gad, Roberts, Steven A, Dmitry A Gordenin, Grimm, Sara A   +29 more
core   +1 more source

STK11 Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical Adenocarcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
STK11 alterations, including mutations, focal deletions, and structural disruption of chromosome 19p, define a distinct molecular subgroup of cervical adenocarcinoma associated with younger age at diagnosis, poorer survival, and reduced benefit from immune checkpoint inhibitors, supporting improved molecular classification and future precision ...
Emma W. Robinson, Elisabeth A. Murphy, Anaseidy Albanez, Sonam Tulsyan, Hong Lou, Yi Xie, Weiyin Zhou, Qian Yang, Tawnjerae Joe, Tongwu Zhang, Jia Liu, Wen Luo, Dongjing Wu, Herbert Higson, Mathias Viard, Mary Carrington, Matthew Oberley, Hesler Morales, Lisa Mirabello, Enrique Alvirez, Roberto Orozco, Eduardo Gharzouzi, Michael Dean   +22 more
wiley   +1 more source

The involvement of hypoxia in APOBEC-mediated mutagenesis in multiple cancers [PDF]

, 2019
Mutational signatures have been studied to associate mutations to their originating causes. One such signature is that of the APOBEC family of proteins.
Liang, Jiachen
core   +1 more source