Results 71 to 80 of about 10,630 (206)
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
iMetaOmics, Volume 3, Issue 3, September 2026.In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
Molecular targeting of mutagenic AID and APOBEC deaminases [PDF]
Cell Cycle, 2013 Purposeful genomic mutation mediates critical aspects of both adaptive and innate immunity. A physiological role for purposeful mutation is best illustrated by the AID/APOBEC family of enzymes, which can deaminate cytosine to introduce rogue uracil bases into DNA.1 In adaptive immunity, introduction of unnatural uracil into the immunoglobulin locus by ...
Nabel, Christopher S +2 more
openaire +2 more sources
Cell Reports, 2019 Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using ...
Nitin Roper +20 more
doaj +1 more source
High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn +6 more
wiley +1 more source
The role of APOBEC proteins in HPV-induced carcinogenesis [PDF]
, 2022 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC) are a family of evolutionarily conserved cytidine deaminases with the ability to bind and modify RNA and/or ssDNA. APOBEC1-4 have a number of functions in cells.
Frolíková, Daniela
core
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Human Genomics, 2018 Background The APOBEC gene family of cytidine deaminases plays important roles in DNA repair and mRNA editing. In many cancers, APOBEC3B increases the mutation load, generating clusters of closely spaced, single-strand-specific DNA substitutions with a ...
Suleyman Vural +2 more
doaj +1 more source
CA: A Cancer Journal for Clinicians, Volume 76, Issue 5, September/October 2026.Abstract The clinical landscape of early stage non–small cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low‐dose computed tomography screening, the frequent detection of ground‐glass opacities, and a rising incidence among never‐smokers, the diagnostic center of gravity has shifted toward earlier, potentially ...
Chaoqi Zhang +23 more
wiley +1 more source
Role of APOBEC deaminases in human tumor virus infection [PDF]
, 2017 本研究では、免疫系の効果分子APOBECとヒト腫瘍ウイルスの代表であるパピローマウイルス(HPV)やB型肝炎ウイルス(HBV)との関係性を調べた。その結果、APOBECはHPVの粒子形成プロセスに干渉し、感染性を低下させ、あるいはウイルスDNAに変異を作る事が明らかになった。またAPOBECがHBVのウイルスRNAを破壊する活性を持つ事がわかった。 これらの研究により、免疫系の持つHBVやHPVに対する感染防御力の一つにAPOBECという宿主酵素群が関与する可能性が浮上し、その機構の一旦が明らかになった。
20359813, 村松, 正道, 86440
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