Results 91 to 100 of about 10,630 (206)

AID and APOBECs span the gap between innate and adaptive immunity

Frontiers in Microbiology, 2014
The AID/APOBEC cytidine deaminases participate in a diversity of biological processes from the regulation of protein expression to embryonic development and host defenses. In its classical role, AID mutates germline-encoded sequences of B cell receptors,
Arnaud eMoris, Shannon M Murray, Sylvain eCardinaud   +2 more
doaj   +1 more source

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer

, 2019
International audienceFGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC→TGC), represents an APOBEC-type motif and is ...
Lamy, Philippe, Banday, A. Rouf, Dyrskjøt, Lars, Meng, Xiang-Yu, Chen, Chun-Long, Bernard-Pierrot, Isabelle, Yang, Jie, Radvanyi, François, Moreno-Vega, Aura, Shi, Ming-Jun, Prokunina-Olsson, Ludmila   +10 more
core   +1 more source

Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer

Molecular Genetics & Genomic Medicine, 2019
Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj   +1 more source

High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity

Retrovirology, 2009
Human APOBEC3G is an antiretroviral protein that was described to act via deamination of retroviral cDNA. However, it was suggested that APOBEC proteins might act with antiviral activity by yet other mechanisms and may also possess RNA deamination ...
Münk Carsten, Flory Egbert, Ehrhardt Christina, Hofmann Henning, Schmolke Mirco, Pauli Eva-K, Ludwig Stephan   +6 more
doaj   +1 more source

Identification of HIV-1 Vif Protein Attributes Associated With CD4 T Cell Numbers and Viral Loads Using Artificial Intelligence Algorithms

IEEE Access, 2020
The Human Immunodeficiency Virus (HIV) Viral Infectivity Factor (Vif) is a 192-amino acid accessory protein essential to viral replication which counteracts host APOBEC3 proteins. APOBEC3 proteins interfere with the replication of HIV, hepatitis C virus,
Jose S. Altamirano-Flores, Sandra E. Guerra-Palomares, Pedro G. Hernandez-Sanchez, Jose L. Ramirez-Garcialuna, J. Rafael Arguello-Astorga, Daniel E. Noyola, Juan C. Cuevas-Tello, Christian A. Garcia-Sepulveda   +7 more
doaj   +1 more source

APOBEC3A mRNA transcript levels correlate with the extent of APOBEC-induced mutations in BRCA cell lines.

, 2019
The average mutation profiles of (A) 14 non-APOBEC-mutated and (B) 14 APOBEC-mutated BRCA cell lines. Specific cell lines in each category are defined in S2 Table.
Christopher D. Collins (2959212), Debra Mitchell (8129844), Amber L. Brown (8129838), Luis M. Cortez (8129835), Alexander J. Brown (6018602), Madeline A. Dennis (8129841), Tony M. Mertz (8129847), Steven A. Roberts (8129850)   +7 more
core   +1 more source

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

, 2016
APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA).
Soldatov, Ruslan A, Seplyarskiy, Vladimir B, Popadin, Konstantin, Nikolaev, Sergey Igorievich, Ruslan A. Soldatov, Antonarakis, Stylianos, Vladimir B. Seplyarskiy, Konstantin Y. Popadin, Stylianos E. Antonarakis, Sergey I. Nikolaev, Georgii A. Bazykin, Bazykin, Georgii A   +11 more
core   +1 more source

Biological and Prognostic Impact of Apobec-Induced Mutations in the Spectrum of Plasma Cell Dyscrasias [PDF]

, 2017
In multiple myeloma (MM), whole exome sequencing (WES) studies have revealed four mutational signatures: two associated with aberrant activities of APOBEC cytidine deaminases (Signatures #2 and #13) and two clock-like signatures associated with "cancer ...
Fullam, Anthony, Munshi, Nikhil, Winnie Liang, Ludmil Alexadrov, Petljak, Mia, Anderson, Kenneth C., Fancesco Maura, Szalat, Raphael, Keats, Jonathan, Anthony Fullam, Jonathan Keats, Hervé Avet-Loiseau, Martincorena, Inigo, Angelopoulos, Nicos, Marta Lionetti, Lionetti, Marta, Bolli, Niccolo, Nicos Angelopoulos, Paolo Corradini, Minvielle, Stephane, Kevin J Dawson, Alexadrov, Ludmil, Nikhil Munshi, Kenneth C Anderson, Mehmet K. Samur, Corradini, Paolo, Neri, Antonino, Campbell, Peter J., Mia Petljak, Eva Pinatel, Liang, Winnie, Cifola, Ingrid, Inigo Martincorena, Niccolò Bolli, Raphael Szalat, Maura, Francesco, Samur, Mehmet K., Avet-Loiseau, Herve, Peter J Campbell, Ingrid Cifola, Dawson, Kevin J., Stephane Minvielle, Antonino Neri, Pinatel, Eva   +43 more
core   +1 more source

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

Oncotarget, 2014
APOBEC cytidine deaminase activity is a major source of hypermutation in cancer. But previous studies have shown that the TC context signature of these enzymes is not observed in sizable fractions of cancers with overexpression of APOBEC, suggesting that cooperating factors that contribute to this mutagenesis should be identified. The fragile histidine
Catherine E, Waters, Joshua C, Saldivar, Zaynab A, Amin, Morgan S, Schrock, Kay, Huebner   +4 more
openaire   +3 more sources

Production of rabbit polyclonal antibody against apobec-1 by genetic immunization

Journal of Lipid Research, 1997
Circulating apolipoprotein B (apoB) exists in two forms; apoB-100 and apoB-48. ApoB-48 is a truncated form of apoB resulting from RNA editing. The editing enzyme, called apobec-1, converts a cytidine (C) at nucleotide 6666 in apoB 100 mRNA to a uridine ...
S C Yeung, J Anderson, K Kobayashi, K Oka, L Chan   +4 more
doaj   +1 more source