Results 101 to 110 of about 10,630 (206)

APOBEC cellular enzymes as ‘Court Jesters’ in SARS-CoV-2 evolution

Human cellular APOBEC enzymes were largely reported as involved in innate antiviral defenses. We previously highlighted that in SARS-CoV-2 genomes obtained in our center, nearly half of ‘hyperfertile’ or ‘fertile’ mutations while 23% of neutral/weakly ...
Levasseur, Anthony, Colson, Philippe, Fantini, Jacques, Devaux, Christian, Pontarotti, Pierre, Raoult, Didier   +5 more
core   +6 more sources

Analyse des mutagenen Einflusses von APOBEC auf den Tropismus von HIV-1 [PDF]

, 2015
Bei der Infektion von Zielzellen bindet HIV außer an CD4 auch die Korezeptoren CCR5 oder CXCR4, weshalb die Viren in CCR5- (R5) und CXCR4-trope Viren (X4) eingeteilt werden. Während CCR5-trope Viruspopulationen in frühen Stadien der Infektion dominieren,
Heger, Eva
core   +1 more source

ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice

Journal of Lipid Research, 2002
Apolipoprotein E (apoE) is essential for the clearance of plasma chylomicron and VLDL remnants. The human APOE locus is polymorphic and 5–10% of APOE*2 homozygotes exhibit type-III hyperlipoproteinemia (THL), while the remaining homozygotes have less ...
Myron E. Hinsdale, Patrick M. Sullivan, Hafid Mezdour, Nobuyo Maeda   +3 more
doaj   +1 more source

Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries

Biological Procedures Online
Background The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family plays a vital mutagenic role in diverse human malignancies.
Wei Luo, Feng Liu, Mengyu Li, Jialong Yu, Ziyun Liu, Xuan Cheng, Yue Huang, Yu Liu, Mei Tao, Yuqi Wang, Yiping Zou, Xiaobin Shang, Chao Yang, Xianhui Ruan, Yanchao Qin, Xiangqian Zheng   +15 more
doaj   +1 more source

Effect of APOBEC proteins on the HPV infection [PDF]

, 2018
Humani virusi papiloma (HPV) so povzročitelji najpogostejše spolno prenosljive okužbe, povezani pa so tudi z razvojem raka materničnega vratu. Proteini APOBEC so DNA/RNA editirajoči encimi, ki igrajo ključno vlogo pri prirojenih protivirusnih imunskih ...
Lojpur, Tjaša
core  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

DNA sequence specificity of APOBEC family deaminases

, 2007
APOBEC family deaminases are capable of causing mutations by deaminating cytosine in DNA to uracil. This is exploited in diversification of the repertoire of antibodies by somatic hypermutation, and also in restricting the spread of retroviruses.
Beale, R C L
core  

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

, 2017
BackgroundThe APOBEC family of enzymes is responsible for a mutation signature characterized by a TCW>T/G mutation. APOBEC-mediated mutagenesis is implicated in a wide variety of tumors, including bladder cancer.
Kalen J. Rimar, Joshua J. Meeks, Damiano Fantini, Alexander P. Glaser   +3 more
core   +1 more source

Abstract 1292: Germline genetic, molecular and environmental factors modulate APOBEC mutagenesis in human tumors

, 2017
Background: Activity of APOBEC3 enzymes has been identified as a main source of somatic mutations of a specific type (C to T or G substitutions in the TCA or TCT motifs).
Ludmila Prokunina-Olsson, Ariunaa Bayanjargal, Olusegun O Onabajo, A. Rouf Banday, Krizia-Ivana Udquim   +4 more
core   +1 more source

Apobecs and mutagenicity.

We demonstrate using cells engineered to express Apobec3b in a doxycycline-inducible fashion and RNA-sequencing evidence supporting mutagenic properties of Apobec family in human cells including an interaction between Neat1 and Apobec3b. We present additional evidence describing Apobec activity in human cancer including triple negative breast cancer ...
  +6 more sources