Results 81 to 90 of about 10,630 (206)

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response

Frontiers in Molecular Biosciences
The APOBEC (Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) family of cytidine deaminases has emerged as pivotal a contributor to genomic instability and adaptive immunity through DNA/RNA editing. Accumulating evidence underscores their
Haiqi Lu, Zelin Lu, Yufei Wang, Miaoqin Chen, Guangliang Li, Xian Wang   +5 more
doaj   +1 more source

The AID/APOBEC family of nucleic acid mutators [PDF]

Genome Biology, 2008
The AID/APOBECs, a group of cytidine deaminases, represent a somewhat unusual protein family that can insert mutations in DNA and RNA as a result of their ability to deaminate cytidine to uridine. The ancestral AID/APOBECs originated from a branch of the zinc-dependent deaminase superfamily at the beginning of the vertebrate radiation. Other members of
openaire   +2 more sources

Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature

Cell Genomics
Summary: Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) enzymes mutate specific DNA sequences and hairpin-loop structures, challenging the distinction between passenger and driver hotspot mutations.
J. Alberto Nakauma-González, Maud Rijnders, Minouk T.W. Noordsij, John W.M. Martens, Astrid A.M. van der Veldt, Martijn P.J. Lolkema, Joost L. Boormans, Harmen J.G. van de Werken   +7 more
doaj   +1 more source

Developmental regulation of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (APOBEC-1) in human small intestine.

Journal of Lipid Research, 1995
Apolipoprotein (apo) B mRNA editing is a site-specific cytidine deamination reaction responsible for the production of apoB-48 in mammalian small intestine. This process is mediated by an enzyme complex that includes the catalytic subunit, APOBEC-1.
F. Giannoni, S.C. Chou, S.F. Skarosi, M.S. Verp, F.J. Field, R.A. Coleman, N.O. Davidson   +6 more
doaj   +1 more source

MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets

Life Science Alliance, 2020
This study reports a new, non-covalent strategy—called MagnEdit—that attracts the DNA cytosine deaminase APOBEC3B to a Cas9-directed site for C-to-T editing.
Jennifer L McCann, Daniel J Salamango, Emily K Law, William L Brown, Reuben S Harris   +4 more
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis [PDF]

, 2019
Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate ...
Zotova, Irina, Pavlov, Youri, Stepchenkova, Elena   +2 more
core   +1 more source

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

Frontiers in Molecular Neuroscience, 2018
C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease.
Svenja Kankowski, Benjamin Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker, Xintian A. You, Marcus Semtner, Florian Hetsch, Jochen C. Meier   +8 more
doaj   +1 more source

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‐FGT) is characterised by an enrichment of pathogenic germline variants in cancer‐predisposition genes, particularly BRCA1 and other homologous recombination repair genes. Recurrent TP53 mutations are concentrated in malignant lesions, while clonal and functional analyses ...
Ying Yuan, Li Zhang, Jiongbo Liao, Bo Wang, Linghui Lu, Dongchen Chu, Yue Shi, Jiaqi Liu, Feng Zhang, Shuyan Tang, Chao Wang   +10 more
wiley   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source