Results 111 to 120 of about 10,630 (206)
Distinct Promoters Induce APOBEC-1 Expression in Rat Liver and Intestine
, 1998 —The expression of apolipoprotein (apo) B can be modulated by mRNA editing, a unique posttranscriptional base change in the apo B mRNA. Apo B-48, the translation product of edited apo B mRNA, is not a precursor of the atherogenic low density lipoproteins
Jobst Greeve +4 more
core +1 more source
Genomic characterization of tumor mutational burden-high breast carcinomas
npj Precision OncologyTumor mutational burden (TMB) has emerged as a potential surrogate for neoantigen load and an indicator of immune checkpoint (IC)-blockade response; however, its precise significance in breast cancer (BC) is not fully understood. Here, we comprehensively
Theodore Vougiouklakis +10 more
doaj +1 more source
Correlation of A3A expression with APOBEC-induced mutations in multiple cancer types.
, 2019 RSEM normalized RNA-seq values for A3A (blue) and A3B (red) were obtained for 410 bladder (BLCA), 197 cervical (CESC), and 549 head and neck (HNSC) cancers assessed by the Cancer Genome Atlas.
Christopher D. Collins (2959212) +7 more
core +1 more source
Scientific ReportsThe APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated.
Ahmadreza Niavarani
doaj +1 more source
Characterizing Somatic Mutation Clusters in Cancers Enriched with APOBEC Mutagenesis
The APOBEC family of cytidine deaminases plays an active role in the human immune system, combating viruses and transposable elements. These enzymes convert cytosine to uracil, which often leads to C->T or C->G mutations within the specific nucleotide
Kazanov, Fedor +2 more
core
Human Papillomavirus Carcinogenesis Mediated by APOBEC Mutagenesis
YAKUGAKU ZASSHI, 2019 Persistent infection with oncogenic human papillomaviruses (HPVs) is necessary for the development of cervical cancer, although the accumulation of somatic mutations in the host genome is also required for the generation of invasive cervical cancer. Recent studies have demonstrated concomitant genetic changes in the HPV genome; however, their relevance
openaire +3 more sources
The apobec mutational activity in multiple myeloma: from diagnosis to cell lines [PDF]
, 2017 Next generation sequencing (NGS) studies have highlighted the role of aberrant activity of APOBEC DNA deaminases in generating the mu- tational repertoire of multiple myeloma (MM).
P. Tarpey +29 more
core
HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation. [PDF]
J Infect DisIllescas-López M +13 more
europepmc +1 more source