APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable
Clinical Cancer Research, 2021 The apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) family protects against infection by degrading incoming viral genomes through cytosine deamination.
Richard G. Vile +9 more
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MicroRNAs regulate APOBEC gene expression [PDF]
Histology and histopathology, 2018 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) is a family of evolutionarily conserved cytidine deaminases, encoded by eleven genes located in the human genome.
Cao, Wei, Wu, Wei
core +4 more sources
The Role of APOBECs in Viral Replication [PDF]
Microorganisms, 2020 Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of functions from tissue-specific gene expression and immunoglobulin ...
Wendy Kaichun Xu +2 more
doaj +3 more sources
APOBEC Mutagenesis in Cancer Development and Susceptibility
CancersAPOBEC cytosine deaminases are prominent mutators in cancer, mediating mutations in over 50% of cancers. APOBEC mutagenesis has been linked to tumor heterogeneity, persistent cell evolution, and therapy responses.
Mia Petljak +3 more
core +3 more sources
A Viral Protein Antagonist for Both AID and APOBEC3 [PDF]
VirusesThe APOBEC family of cytidine deaminases is part of the innate immune response to infections by multiple RNA- and DNA-containing viruses. Since the activity of these enzymes, typically APOBEC3, often involves mutations that inhibit or block viral ...
Jaquelin P. Dudley
doaj +2 more sources
Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer [PDF]
Frontiers in ImmunologyBackgroundAPOBEC cytidine deaminases generate characteristic TCW-context mutations that diversify cancer genomes, yet their functional impact on colorectal cancer (CRC) progression and the tumor microenvironment (TME) remains poorly defined.MethodsWe ...
Junting Chen +4 more
doaj +2 more sources
Natural Resistance to HIV Infection: the Vif-APOBEC Interaction [PDF]
C R Biol., 2005 Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection. Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein.
Michael H. Malim +3 more
core +6 more sources
APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development [PDF]
Cell Reports, 2014 APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over 99%
Stephen Henderson +4 more
doaj +2 more sources
HIV-1 Vif, APOBEC, and Intrinsic Immunity [PDF]
Retrovirology, 2008 Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements.
Strebel Klaus, Goila-Gaur Ritu
doaj +3 more sources
Machine learning-driven classification and prognostic prediction of kidney renal clear cell carcinoma using APOBEC family expression signatures [PDF]
Scientific ReportsApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases are a highly evolutionarily conserved protein family. Their members are closely associated with DNA damage repair and involved in the genesis and progression of
Zhen Ren +15 more
doaj +2 more sources