Results 51 to 60 of about 5,637 (158)
Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation. [PDF]
Sci AdvCarcinogenesis in human urothelium is driven by a high burden of mutations caused by the antiviral “APOBEC3” (apolipoprotein B mRNA editing enzyme, catalytic subunit–like 3) cytosine deaminase enzymes; however, there is no established viral etiology.
Hatton GH +17 more
europepmc +4 more sources
Advanced Science, Volume 13, Issue 48, 28 August 2026.A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin +15 more
wiley +1 more source
Scientific Reports, 2023 Since November 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the worldwide pandemic of the coronavirus disease 2019 (COVID-19), the impact of which is huge to the lives of world populations.
Ke Zhang +7 more
doaj +1 more source
Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening
Biotechnology Journal, Volume 21, Issue 8, August 2026.Graphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Taeho Yu, Woo Dae Jang, Sang Yup Lee
wiley +1 more source
APOBEC3 genes: retroviral restriction factors to cancer drivers [PDF]
, 2015 The APOBEC3 cytosine deaminases play key roles in innate immunity through their ability to mutagenize viral DNA and restrict viral replication. Recent advances in cancer genomics, together with biochemical characterization of the APOBEC3 enzymes, have ...
Fenton, TR, Fenton, T, Henderson, S
core +1 more source
DHX15 inhibits mouse APOBEC3 deamination.
PLoS PathogensAPOBEC3 family proteins are critical host factors that counteract and prevent the replication of retroviruses and other viruses through cytidine deamination.
Wenming Zhao, Ayan Modak, Susan R Ross
doaj +1 more source
DND1 and APOBEC3 in mouse tissues.
, 2013 (a) DND1 interacts with endogenous APOBEC3. Mouse testis lysates were incubated with GST-DND1α (lane 1), GST-DND1β⪽ (lane 2) or GST protein (lane 3) and incubated with Sepharose 4B beads.
Sita Aggarwal (47612) +4 more
core +1 more source
Retróveiruhindrinn APOBEC3 í klaufdýrum
, 2009 The APOBEC3 proteins are a mammalian specific family of nucleic acid cytosine deaminases. A number of family members, including the most studied family member human APOBEC3G, have been shown to be able to inhibit retroviral infection by causing C to U ...
Stefán Ragnar Jónsson 1977-
core +1 more source
Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice. [PDF]
PLoS ONE, 2013 Understanding the host genetics of the immune response in retrovirus infection models could provide insights for basic HIV vaccine discovery. In Friend retrovirus (FV) infection of mice, Fv1 differentially inhibits N-tropic versus B-tropic FV infection ...
Kalani Halemano +6 more
doaj +1 more source
Diagnostics, 2023 The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) is largely documented in the literature, but further research is needed to determine how they influence carcinogenesis.
Nathália de Sousa Pereira +2 more
doaj +1 more source