Results 61 to 70 of about 5,637 (158)

Hypoxia Independently Induces AID Expression in CH12 B Cells

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Hypoxia activates the HIF complex (HIF‐1α, HIF‐1β, HIF‐2α) to induce AID expression in B cells independently of cytokine signaling. However, hypoxia alone is insufficient to trigger class switch recombination (CSR), which additionally requires cytokine‐driven chromatin accessibility, highlighting a mechanistic uncoupling between AID induction and ...
Vincent Heyer, Sandy Haidar Ahmad, Mira Haddad, Inès Argentieri, Coraline Gessier, Bernardo Reina‐San‐Martin   +5 more
wiley   +1 more source

Trends of Pathogenicity and Potential Risk Evaluation of Central African Mpox Variant to Cause Global Public Health Emergency: A Cross‐Sectional Analysis

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background With the re‐emergence of monkeypox (Mpox), it is vital for communities to assess and effectively respond to emerging outbreaks. This paper aims to review the potential of clade I Mpox to result in a widespread outbreak by assessing genetically enhanced virulence, transmission, and clinical manifestations.
Md. Ashrafur Rahman, Carlie Kozlowich, Nicholas Katulka, Marie Roke Thomas, Yeasna Shanjana, Md. Rabiul Islam   +5 more
wiley   +1 more source

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Nature Communications, 2020
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to
Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile   +19 more
doaj   +1 more source

KSHV Genome in Saliva, Whole Blood and Kaposi's Sarcoma Biopsy Specimens in Republic of Congo: Phylogenetic Analysis and an APOBEC3B Mutational Signature

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) has been associated with a variety of diseases and is endemic in Sub‐Saharan Africa. We performed KSHV‐whole‐genome analysis and search for APOBEC‐editing to describe genetic diversity in samples issued from an endemic region.
Gervillien Arnold Malonga, Valentin Leducq, Antoine Fauchois, Dimitry Moudiongui Mboungou Malanda, Patrina Joseph Iloukou Mayakia, Juthèce Private Malanda‐Kiminou, Ferdinand Emaniel Brel Got, Fabien Gaël Mouamba, Vincent Calvez, Jean Felix Peko, Anne‑Geneviève Marcelin, Aude Jary   +11 more
wiley   +1 more source

EBV Genome Variations and Association With Diseases

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin, Jingtong Liang, Qiuting Zhang, Qinyao Huang, Xinyu Zhang, Miao Xu   +5 more
wiley   +1 more source

The coevolution between APOBEC3 and retrotransposons in primates

Mobile DNA, 2022
Retrotransposons are genetic elements with the ability to replicate in the genome using reverse transcriptase: they have been associated with the development of different biological structures, such as the Central Nervous System (CNS), and their high ...
Giorgia Modenini, Paolo Abondio, Alessio Boattini   +2 more
doaj   +1 more source

The Genomic Evolution of Early‐Stage Non‐Small Cell Lung Cancer

Medicine Advances, Volume 4, Issue 1, Page 1-9, March 2026.
This study provides a comprehensive overview of the genomic landscape of early‐stage non‐small cell lung cancer, identifying the 4q12 deletion as a potential exclusive biomarker for the “oncogenic switch” from pre‐invasive to invasive lesions. It delineates that while EGFR and TP53 mutations act as early truncal drivers, the progressive increase in ...
Huatao Tang, Yang Zhang, Haiquan Chen
wiley   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Development and validation of a novel prognostic lncRNA signature based on the APOBEC3 family genes in gastric cancer

Heliyon
Introduction: Gastric Cancer (GC) refers to a prevalent malignant cancer accompanied by a weak prognosis. The APOBEC3 family genes and lncRNAs are linked with cancer progression.
Jia Qi, Wenxuan Wu, Jing Chen, Xiaying Han, Zhixing Hao, Yaxuan Han, Yewei Xu, Jun Lai, Jian Chen   +8 more
doaj   +1 more source

Urothelial Carcinoma of the Bladder Following BK Virus Infection in a Pediatric Kidney Transplant Recipient

Pediatric Transplantation, Volume 30, Issue 3, March 2026.
ABSTRACT Background Urothelial bladder carcinoma is extremely rare in children and its association with BK virus infection remains unclear. Methods We describe the case of an 11‐year‐old girl who developed a urothelial carcinoma of the bladder four years after receiving her first kidney transplant.
Martina Ichas, Lise Allard, Luke Harper, Mokrane Yacoub, Iona Madden, Cécile Vérité, Astrid Godron‐Dubrasquet, Jérôme Harambat   +7 more
wiley   +1 more source