Results 81 to 90 of about 5,637 (158)

Molecular mechanism of APOBEC3-mediated inhibition on Gag-Pol autoprocessing [PDF]

, 2019
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08821/研究成果の概要（和文）：APOBEC3は自身の酵素活性を介する機構と介さない機構の両面からウイルス複製を阻害するが、その分子機構の全容は解明されていない。本研究ではAPOBEC3がどのようにHIV-1とMuLVの増殖を阻害するのか、機序解明に取り組んだ。その結果、APOBEC3はウイルス酵素群の前駆体に結合し、その多段階的な切断を経て生じるウイルスプロテアーゼの産生を阻害することで ...
ハカタ, ヨシユキ, 博多, 義之, 宮澤, 正顕, ミヤザワ, マサアキ   +3 more
core   +1 more source

APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution

Heliyon
SARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces of SARS-CoV-2 evolution might be activation of apolipoprotein B mRNA editing catalytic subunit-like protein 3 (APOBEC3) by inflammatory factors.
Jiaying Shen, Xinxin Xu, Junyan Fan, Hongsen Chen, Yue Zhao, Weijin Huang, Wenbin Liu, Zihan Zhang, Qianqian Cui, Qianqian Li, Zheyun Niu, Dongming Jiang, Guangwen Cao   +12 more
doaj   +1 more source

Lentiviral Vif and APOBEC3 diversity and functionality in mammals.

, 2016
(A) The primate lentiviral Vif/CBF-β complex protects viral genetic integrity by polyubiquitinating and degrading cellular APOBEC3 enzymes. (B) Structural representations of the Vif/CBF-β and RUNX/CBF-β heterodimeric complexes (PDB 4N9F and 1H9D ...
Reuben S. Harris (22319), Brett D. Anderson (3371825)   +1 more
core   +1 more source

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model

Frontiers in Genetics
IntroductionThe APOBEC3 family of cytidine deaminases induces somatic mutations that are highly prevalent in cancers, but the functional consequences remain largely unknown.MethodsTo determine these consequences, we exposed MCF7 tumorigenic breast ...
Milaid Granadillo Rodríguez, Lai Wong, Arzhang Shayeganmehr, Diogo Pellegrina, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Franco J. Vizeacoumar, Mohamed Helmy, Mohamed Helmy, Mohamed Helmy, Linda Chelico   +10 more
doaj   +1 more source

Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins.

PLoS Pathogens, 2008
Because of evolutionary pressures imposed through episodic colonization by retroviruses, many mammals express factors, such as TRIM5alpha and APOBEC3 proteins, that directly restrict retroviral replication.
David Perez-Caballero, Steven J Soll, Paul D Bieniasz   +2 more
doaj   +1 more source

hmpxv/apobec3: v2.0

Updating aa calculation code and data files for hMPXV1 and B.1Andrew Rambaut, & Áine O'Toole. (2024). hmpxv/apobec3: v2.0. Zenodo.
Rambaut, Andrew, School of Biological Sciences, O'Toole, Áine   +2 more
core   +1 more source

Localization of APOBEC3 and DND1 in NIH3T3 and 293T cells.

, 2013
(a–d) Co-transfection of mCherry-Apobec3 and GFP-DND1 expression constructs into NIH3T3 cells. Cells were fixed with 2% paraformaldehyde before visualization of fluorescent signal by confocal microscopy.
Sita Aggarwal (47612), Amatul Ali (47613), Chitralekha Bhattacharya (47611), Angabin Matin (47614), Madhu Kumar (8199)   +4 more
core   +1 more source

Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction

Journal of Virology
Several APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-stranded proviral (−)DNA. However, HIV-1 Vif counteracts their activity by inducing their proteasomal degradation.
Amit Gaba, Maria Yousefi, Shreoshri Bhattacharjee, Linda Chelico   +3 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

MicroRNA Regulation of the HIV Restricting Human APOBEC3 Enzymes

, 2019
The human APOBEC3 family of enzymes is composed of seven members that are encoded in tandem on chromosome 22 of the human genome and likely arose by gene duplication in a primate ancestor.
Kennedy, Madeleine, Herber, Hunter, Anderson, Joelle   +2 more
core