Results 91 to 100 of about 5,637 (158)

Innate Retroviral Restriction by Apobec3 Promotes Antibody Affinity Maturation In Vivo

, 2010
Apobec3/Rfv3 is an innate immune factor that promotes the neutralizing Ab response against Friend retrovirus (FV) in infected mice. Based on its evolutionary relationship to activation-induced deaminase, Apobec3 might directly influence Ab class ...
Robert L. Benitez, Kim J. Hasenkrug, Mario L. Santiago, Warner C. Greene, Mauricio Montano   +4 more
core   +1 more source

Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor

, 2018
The apolipoprotein B editing complex 3 (APOBEC3) proteins are potent retroviral restriction factors that are under strong positive selection, both in terms of gene copy number and sequence diversity.
Wenming Zhao, Spyridon Stavrou, Kristin Blouch, Susan R. Ross   +3 more
core   +1 more source

APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers

Viruses
The human APOBEC superfamily consists of eleven cytidine deaminase enzymes. Among them, APOBEC3 enzymes play a dual role in antiviral immunity and cancer development. APOBEC3 enzymes, including APOBEC3A (A3A) and APOBEC3B (A3B), induce mutations in viral
Eliza Pizarro Castilha, Rosalba Biondo, Kleber Paiva Trugilo, Giulia Mariane Fortunato, Timothy Robert Fenton, Karen Brajão de Oliveira   +5 more
doaj   +1 more source

APOBEC3 subcellular localization and genomic editing

, 2012
University of Minnesota Ph.D. dissertation. October 2012. Major: Biochemistry, Molecular Bio, and Biophysics. Advisor: Reuben S. Harris. 1 computer file (PDF); ix, 182 pages.The APOBEC proteins are DNA cytosine deaminases with roles in immunity ...
Lackey, Lela Lynn
core  

APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy

Molecular Therapy: Oncology
Chimeric antigen receptor (CAR) T cells are a clinically approved therapy for blood cancers. To produce clinical-grade CAR T cells, a retroviral or lentiviral vector is used to deliver the CAR and associated genes to patient T cells.
Jack Swanson, Jason Tonne, Thanich Sangsuwannukul, Jill Thompson, Benjamin Kendall, Olivia Liseth, Muriel Metko, Richard Vile   +7 more
doaj   +1 more source

Abstract 4249: Evidence of APOBEC3 editing in the HPV16 genome

, 2017
Human papillomavirus (HPV) is a very common sexually transmitted infection, however only a small proportion of women progress to cervical precancer or cancer.
Yanzi Xiao, Lisa Mirabello, Zigui Chen, Bin Zhu, Laurie Burdette, Kai Yu, Tina Raine-Bennett, Thomas Lorey, Sara Bass, Philip Castle, Joseph Boland, Mia Steinberg, Mark Schiffman, Michael Cullen, Nicolas Wentzensen, Robert Burk, Qi Yang, David Roberson, Meredith Yeager   +18 more
core   +1 more source

Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3

, 2017
The interplay between viral and host proteins has been well studied to elucidate virus-host interactions and their relevance to virulence. Mammalian genes encode apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins, which ...
Naoko Misawa, Yusuke Nakano, Yuichi Kimura, Fengrong Ren, Junko S. Takeuchi, Rokusuke Yoshikawa, Eri Yamada, Yoshio Koyanagi, Takayuki Miyazawa, Kei Sato   +9 more
core   +1 more source

APOBEC3 proteins restrict mobile and foreign DNA

, 2009
University of Minnesota Ph.D. dissertation. August 2009. Major: Biochemistry, Molecular Bio, and Biophysics. Advisor: Reuben S. Harris.viii, 130 pages. Ill. (some col.)A cell's DNA provides its operating instructions.
Stenglein, Mark Daniel
core  

APOBEC3 Transcriptional Regulation and HIV-1 Restriction in T Lymphocytes

, 2017
University of Minnesota Ph.D. dissertation. August 2017. Major: Biochemistry, Molecular Bio, and Biophysics. Advisor: Reuben Harris. 1 computer file (PDF); ix, 99 pages.Human immunodeficiency virus type-1 (HIV-1), the etiologic agent of acquired ...
Anderson, Brett
core  

Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus

The seven human APOBEC3 (hA3) genes encode polynucleotide cytidine deaminases that play vital roles in restricting replication of viruses and retrotransposons.
Prosser, Haydn M., Reddin, Ian, Bishop, Kate N., Bradley, Allan, Periyasamy, Manikandan, Scott, James, Gibson, Jane, Stranger, Ane, Zainal, Nur, Thomas, Gareth J., Kirkwood, Nerissa K., Fenton, Tim, Cook, Ross, Howes, Emma, Conticello, Silvestro G., Yap, Melvyn W., Ali, Simak   +16 more
core   +1 more source