Results 71 to 80 of about 5,637 (158)
Evolvability of cancer-associated genes under APOBEC3A/B selection
iScienceSummary: Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and genetic variation. Mutations generated by APOBEC3 contribute to genetic variation and tumor evolvability.
Joon-Hyun Song +3 more
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 2, Page 397-411, February 2026.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion [PDF]
, 2005 While members of the APOBEC3 family of human intrinsic resistance factors are able to restrict the replication of Vif-deflcient forms of human immunodeficiency virus type 1 (HIV-1), they are unable to block replication of wild-type HIV-1 due to the ...
Wiegand, H.L +4 more
core +1 more source
From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
APOBEC3 mutation signature analysis using an alternative NMF-based workflow.
, 2023 (A) Mutation signature profiles extracted from granddaughter clone WGS using an NMF-based approach. The SBSs of each clone resolved into 2 signatures—an APOBEC3-like mutation signature shown in red and a background signature in blue.
William L. Brown (13813259) +9 more
core +1 more source
Advances in Public Health, Volume 2026, Issue 1, 2026.The global public health landscape in 2024 is defined by overlapping crises that strain health systems, deepen inequities, and demand urgent multisectoral responses. This comprehensive review examines the critical intersection of these challenges.
Olalekan John Okesanya +10 more
wiley +1 more source
Human immunodeficiency virus evasion of APOBEC3 restriction factors [PDF]
, 2012 University of Minnesota Ph.D. dissertation. October 2012. Major: Microbiology, Immunology and Cancer Biology. Advisor: Reuben S. Harris. 1 computer file (PDF); xviii, 349 pages, appendix 1.The human immunodeficiency virus accessory protein Vif protects ...
Albin, John Squire
core
DHX15 inhibits mouse APOBEC3 deamination activity
APOBEC3 family proteins are critical host proteins that counteract and prevent the replication of retroviruses and other viruses through cytidine deamination. Human APOBEC3G inactivates HIV-1 through the introduction of lethal mutations to viral genomes.
zhao, wenming
core +1 more source
Cellular localization of APOBEC3 proteins.
, 2023 Confocal microscopy of V5-tagged A3A-A3H plasmids performed in HeLa cells at 24 hours post transfection. Nuclei are stained using DAPI (blue), and mitochondrial network detection was performed with anti-TOM20 (red), APOBEC3 with anti-V5 (green), and ...
Chantal Combredet (273015) +14 more
core +1 more source
In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
doaj +1 more source