Results 41 to 50 of about 5,637 (158)

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Atypical Varicella‐Like Presentation of an Imported Mpox Case in Austria Confirmed to be Infected With Clade Ib

JEADV Clinical Practice, EarlyView.
ABSTRACT The recent upsurge of cases caused by the newly identified Clade Ib monkeypox virus (MPXV) in the Democratic Republic of the Congo and other countries has emerged as a significant public health concern. A 34‐year‐old male tourist from Venezuela presented in Vienna, Austria, during his travels through Europe with fever, pharyngitis and an ...
Amélie Hampel, David N. Springer, Jeremy V. Camp, Stephan W. Aberle, Maximilian Egg, Luigi Segagni Lusignani, Katharina Grabmeier‐Pfistershammer, Robert Strassl, Judith Wendt, Tamar Kinaciyan, Alessandra Handisurya   +10 more
wiley   +1 more source

Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

PLoS Pathogens, 2014
Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition.
Eun-Young Kim, Ramon Lorenzo-Redondo, Susan J Little, Yoon-Seok Chung, Prabhjeet K Phalora, Irina Maljkovic Berry, John Archer, Sudhir Penugonda, Will Fischer, Douglas D Richman, Tanmoy Bhattacharya, Michael H Malim, Steven M Wolinsky   +12 more
doaj   +1 more source

Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys

Retrovirology, 2011
Background The cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) are innate cellular factors that inhibit replication of a number of viruses, including HIV-1. Since antiviral activity of APOBEC3 has been mainly confirmed by in vitro data, we examined
Stahl-Hennig Christiane, Motzkus Dirk, Sauermann Ulrike, Mußil Bianka, Sopper Sieghart   +4 more
doaj   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

APOBEC3 inhibits DEAD-END function to regulate microRNA activity [PDF]

, 2013
The RNA binding protein DEAD-END (DND1) is one of the few proteins known to regulate microRNA (miRNA) activity at the level of miRNA-mRNA interaction. DND1 blocks miRNA interaction with the 3′-untranslated region (3′-UTR) of specific mRNAs and restores ...
Stenglein, Mark D, Mark D Stenglein, April J Schumacher, Ali, Sara, Demorest, Zachary L, Matin, Angabin, MacDuff, Donna A, Chitralekha Bhattacharya, Harris, Reuben S, Rui Zhu, Bhattacharya, Chitralekha, Reuben S Harris, Karki, Namrata, Sita Aggarwal, Sara Ali, Angabin Matin, Aggarwal, Sita, Zachary L Demorest, Namrata Karki, Schumacher, April J, Donna A MacDuff, Zhu, Rui   +21 more
core   +1 more source

Clinical Implications of APOBEC3-Mediated Mutagenesis in Breast Cancer

, 2022
Over recent years, members of the APOBEC3 family of cytosine deaminases have been implicated in increased cancer genome mutagenesis, thereby contributing to intratumor and intertumor genomic heterogeneity and therapy resistance in, among others, breast ...
Roelofs, Pieter A, Martens, John W M, Span, Paul N, Harris, Reuben S, John W.M. Martens, Paul N. Span, Reuben S. Harris, Pieter A. Roelofs   +7 more
core   +1 more source

Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements

Retrovirology, 2008
Background APOBEC3 cytosine deaminases have been demonstrated to restrict infectivity of a series of retroviruses, with different efficiencies depending on the retrovirus.
Heidmann Odile, Ribet David, Priet Stéphane, Esnault Cécile, Heidmann Thierry   +4 more
doaj   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Clinical Implications of APOBEC3-Mediated Mutagenesis in Breast Cancer. [PDF]

, 2023
Over recent years, members of the APOBEC3 family of cytosine deaminases have been implicated in increased cancer genome mutagenesis, thereby contributing to intratumor and intertumor genomic heterogeneity and therapy resistance in, among others, breast ...
Span, P.N., Roelofs, P.A., Harris, R.S., Martens, J.W.M.   +3 more
core