Results 21 to 30 of about 5,637 (158)

APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types

BMC Biology, 2022
Background The APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide 3) family of cytidine deaminases is responsible for two mutational signatures (SBS2 and SBS13) found in cancer genomes.
G. Maria Jakobsdottir, Daniel S Brewer, Colin Cooper, Catherine Green, David C Wedge   +4 more
doaj   +1 more source

APOBEC3-mediated restriction of RNA virus replication [PDF]

, 2018
APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus.
Marek Ochman, Pyrć, Krzysztof, Kindler, Eveline, V'Kovski, Philip, Aleksandra Milewska, Milewska, Aleksandra, Thiel, Volker, Slawomir Zeglen, Eveline Kindler, Zeglen, Slawomir, Philip Vkovski, Zenon Rajfur, Vkovski, Philip, Zeglen, S, Volker Thiel, Ochman, M, Thiel, Volker Earl, Rajfur, Z, Rajfur, Zenon, Kindler, Eveline Patricia, Pyrc, K, Ochman, Marek, Krzysztof Pyrc   +22 more
core   +3 more sources

hmpxv/apobec3: v1.0.1

, 2023
# apobec3 Repository for supplementary materials for hMPXV-1 APOBEC3 ...
Rambaut, Andrew, School of Biological Sciences, O'Toole, Áine   +2 more
core   +1 more source

Investigation of APOBEC3 regulation and function in cancer [PDF]

, 2021
The APOBEC3 gene family of cytosine deaminases has a diverse range of functions which have not been fully elucidated. The human APOBEC3 gene family is thought to be involved in the restriction of viruses as well as retrotransposons, however recently the ...
Venkatesan, Subramanian
core   +1 more source

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

Retrovirology, 2017
Background APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a potent type I ...
Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug, Mario L. Santiago   +7 more
doaj   +1 more source

Vaccinia virus replication is not affected by APOBEC3 family members [PDF]

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source

Functions, structure, and read-through alternative splicing of feline APOBEC3 genes [PDF]

, 2008
Background Over the past years a variety of host restriction genes have been identified in human and mammals that modulate retrovirus infectivity, replication, assembly, and/or cross-species transmission. Among these host-encoded restriction factors, the
Marion Battenberg, O'Brien, Stephen J., Hotz-Wagenblatt, Agnes, Battenberg, Marion, Thomas Beck, Sarah Chareza, O\u27Brien, Stephen J., Thielebein, Jens, Jörg Zielonka, Münk, Carsten, Cichutek, Klaus, Beck, Thomas W., Zielonka, Jörg, Chareza, Sarah, Bravo, Ignacio G., Beck, Thomas, Jens Thielebein, Klaus Cichutek, Ignacio G Bravo, Löchelt, Martin, Martin Löchelt, Carsten Münk, Agnes Hotz-Wagenblatt, Yuhki, Naoya, Stephen J O'Brien, Naoya Yuhki   +25 more
core   +1 more source

Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).

PLoS ONE, 2008
BackgroundThe dead-end (Dnd1) gene is essential for maintaining the viability of germ cells. Inactivation of Dnd1 results in sterility and testicular tumors. The Dnd1 encoded protein, DND1, is able to bind to the 3'-untranslated region (UTR) of messenger
Chitralekha Bhattacharya, Sita Aggarwal, Madhu Kumar, Amatul Ali, Angabin Matin   +4 more
doaj   +1 more source

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I

Viruses, 2023
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different efficiencies. The HIV-1 Vif protein combats APOBEC3-mediated restriction by inducing
Maria Yousefi, Arun Kumar Annan Sudarsan, Amit Gaba, Linda Chelico   +3 more
doaj   +1 more source

Footprint of the host restriction factors APOBEC3 on the genome of human viruses.

PLoS Pathogens, 2020
APOBEC3 enzymes are innate immune effectors that introduce mutations into viral genomes. These enzymes are cytidine deaminases which transform cytosine into uracil.
Florian Poulain, Noémie Lejeune, Kévin Willemart, Nicolas A Gillet   +3 more
doaj   +1 more source