Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells [PDF]
Viruses, 2022 Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto +8 more
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Suppression of APOBEC3-mediated restriction of HIV-1 by Vif [PDF]
Frontiers in Microbiology, 2014 The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to suppress replication of viruses with a single-stranded DNA intermediate by inducing mutagenesis and functional inactivation of the virus.
Yuqing eFeng +3 more
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A novel role for APOBEC3: Susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice [PDF]
Retrovirology, 2012 Background APOBEC3 proteins are host factors that restrict infection by retroviruses like HIV, MMTV, and MLV and are variably expressed in hematopoietic and non-hematopoietic cells, such as macrophages, lymphocytes, dendritic, and epithelia cells ...
Jones Philip H +2 more
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A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif
Retrovirology, 2017 Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication.
Yusuke Nakano +7 more
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HIV restriction by APOBEC3 in humanized mice. [PDF]
PLoS Pathogens, 2013 Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit.
John F Krisko +3 more
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Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response. [PDF]
PLoS Pathogens, 2011 Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand ...
Diana S Smith +7 more
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MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing [PDF]
Journal of VirologyThe 2022 outbreak of monkeypox virus (MPXV), a double-stranded DNA virus, is remarkable for an unusually high number of single-nucleotide substitutions compared to earlier strains, with a strong bias toward C→T and G→A transitions consistent with the ...
Alisa O. Lyskova +13 more
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The Intricate Interplay between APOBEC3 Proteins and DNA Tumour Viruses
PathogensAPOBEC3 proteins are cytidine deaminases that play a crucial role in the innate immune response against viruses, including DNA viruses. Their main mechanism for restricting viral replication is the deamination of cytosine to uracil in viral DNA during ...
Nika Lovšin +2 more
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The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead [PDF]
Open Biology, 2020 Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous
Milaid Granadillo Rodríguez +2 more
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Blood Cancer Journal, 2022 Constitutively activated B cell receptor (BCR) signaling is a primary biological feature of chronic lymphocytic leukemia (CLL). The biological events controlled by BCR signaling in CLL are not fully understood and need investigation. Here, by analysis of
Zhiquan Wang +15 more
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