Results 1 to 10 of about 20,255 (238)

Novel Compound Inhibitors of HIV-1_NL4-3 Vpu [PDF]

Viruses, 2022
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate the ...
Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson   +18 more
doaj   +4 more sources

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.

PLoS Pathogens, 2021
The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, but the picture
Charlotte A Stoneham, Simon Langer, Paul D De Jesus, Jacob M Wozniak, John Lapek, Thomas Deerinck, Andrea Thor, Lars Pache, Sumit K Chanda, David J Gonzalez, Mark Ellisman, John Guatelli   +11 more
doaj   +2 more sources

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1 [PDF]

eLife, 2014
BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Xiaofei Jia, Erin Weber, Andrey Tokarev, Mary Lewinski, Maryan Rizk, Marissa Suarez, John Guatelli, Yong Xiong   +7 more
doaj   +3 more sources

Possible Acquisition and Molecular Evolution of vpu Genes Inferred from Comprehensive Sequence Analysis of Human and Simian Immunodeficiency Viruses. [PDF]

J Mol Evol
Vpu, an accessory protein of Human immunodeficiency virus 1 (HIV-1), plays a crucial role in viral particle production and release, contributing to HIV virulence and its associated pandemic.
Naruki M, Saito M, Nomaguchi M, Kanai A.
europepmc   +2 more sources

HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. [PDF]

EMBO Rep
Despite the efficacy of highly active antiretroviral therapy in controlling the incidence and mortality of AIDS, effective interventions for HIV-1-induced neurological damage and cognitive impairment remain elusive.
Yang J, Li Y, Li H, Zhang H, Guo H, Zheng X, Yu XF, Wei W.   +7 more
europepmc   +2 more sources

HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection [PDF]

mSystems
Viral protein U (Vpu), an accessory protein of HIV-1, functions by antagonizing or hijacking various host factors to allow the virus to evade host immune surveillance and facilitate viral release.
Boye Li, Yanzhe Hao, Xianbin Meng, Xiaoming Wang, Qingyan Li, Runqing Jia, Yishu Yang, Jinning Yang, Boyang Yu, Tian Chen, Wenmei Zhang, Xiaoguang Zhang, Xiayan Wang, Qin Hu   +13 more
doaj   +2 more sources

Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors [PDF]

Retrovirology, 2010
Background The gibbon ape leukemia virus (GaLV) Env protein mediates entry into a wide range of human cells and is frequently used to pseudotype retroviral vectors.
Cannon Paula M, Oldenburg Jill E, Droniou-Bonzom Magali E, Christodoulopoulos Ilias   +3 more
doaj   +4 more sources

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

Retrovirology, 2018
Background The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence.
Emily N. Pawlak, Brennan S. Dirk, Rajesh Abraham Jacob, Aaron L. Johnson, Jimmy D. Dikeakos   +4 more
doaj   +2 more sources

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

eLife, 2019
Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting ...
Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter   +13 more
doaj   +2 more sources

Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. [PDF]

PLoS Pathogens, 2009
Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin. Here, we show that positive
Matthew W McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E Johnson, Stuart J D Neil, Paul D Bieniasz   +7 more
doaj   +2 more sources