Results 1 to 10 of about 6,222 (133)

Quantitative and amino acid sequence analysis of soluble HIV-1 Vpu and calmodulin interactions. [PDF]

Protein Sci
Abstract HIV‐1 Vpu supports viral adaptation through host‐protein interactions. Although mainly membrane‐associated, we recently identified a soluble Vpu form that forms a stable complex with Ca2+‐bound calmodulin (Ca2+–CaM), potentially influencing Vpu trafficking. Here, to determine the binding affinity and identify regions of soluble Vpu involved in
Ogunbowale A, Hadadianpour E, Ishola O, Islam MM, Ramos N, Delkhosh AS, Georgieva ER.   +6 more
europepmc   +2 more sources

The soluble state of the HIV-1 Vpu protein forms a complex with Ca²⁺-calmodulin. [PDF]

Protein Sci
Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Ishola O, Islam MM, Hadadianpour E, Borbat PP, Ogunbowale A, Amador JCR, Georgieva ER.   +6 more
europepmc   +2 more sources

HIV-1 Vpr Drives a B Cell-Like Phenotype in Primary CD4⁺ T Cells. [PDF]

MedComm (2020)
During acute HIV‐1 infection, Vpr induces transcriptional and epigenetic remodeling of primary CD4+ T cells, activating a transient B cell‐like program characterized by CD19, MS4A1, CD22, and PAX5 expression and increased chromatin accessibility at lymphocyte differentiation genes.
Wang P, Li J, Wang W, Meng Z, Wu H, Du S, Deng K, Cai J.   +7 more
europepmc   +2 more sources

HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection [PDF]

mSystems
Viral protein U (Vpu), an accessory protein of HIV-1, functions by antagonizing or hijacking various host factors to allow the virus to evade host immune surveillance and facilitate viral release.
Boye Li, Yanzhe Hao, Xianbin Meng, Xiaoming Wang, Qingyan Li, Runqing Jia, Yishu Yang, Jinning Yang, Boyang Yu, Tian Chen, Wenmei Zhang, Xiaoguang Zhang, Xiayan Wang, Qin Hu   +13 more
doaj   +2 more sources

Vpu Protein: The Viroporin Encoded by HIV-1

Viruses, 2015
Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains.
Maria Eugenia Gonzalez
exaly   +3 more sources

Novel Compound Inhibitors of HIV-1_NL4-3 Vpu

Viruses, 2022
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate the ...
Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson   +18 more
doaj   +1 more source

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.

PLoS Pathogens, 2021
The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, but the picture
Charlotte A Stoneham, Simon Langer, Paul D De Jesus, Jacob M Wozniak, John Lapek, Thomas Deerinck, Andrea Thor, Lars Pache, Sumit K Chanda, David J Gonzalez, Mark Ellisman, John Guatelli   +11 more
doaj   +1 more source

Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation

Infectious Medicine, 2023
s: Background: HIV-1 Vpu acts by counteracting the tethering function of tetherin and resulting in the release of HIV-1 virion. Disrupting Vpu-tetherin interactions may provide a promising new target for antiretroviral therapy.
Shuai Chang, Lifeng Cai, Yongchang Yang, Binlian Sun, Jingyun Li, Jie Liu, Lin Li   +6 more
doaj   +1 more source

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.

PLoS Pathogens, 2015
HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu.
Tonya Kueck, Toshana L Foster, Julia Weinelt, Jonathan C Sumner, Suzanne Pickering, Stuart J D Neil   +5 more
doaj   +1 more source

Functional conservation and coherence of HIV-1 subtype A Vpu alleles

Scientific Reports, 2017
Functional studies of HIV-1 proteins are normally conducted using lab adapted strains of HIV-1. The extent of those functions in clinical strains is sometimes unknown.
Bizhan Romani, Amirarsalan Kavyanifard, Elham Allahbakhshi   +2 more
doaj   +1 more source