Vpu Protein: The Viroporin Encoded by HIV-1 [PDF]
Viruses, 2015 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains.
Maria Eugenia Gonzalez
exaly +6 more sources
HIV-1 Vpu Mediates HLA-C Downregulation [PDF]
Cell Host and Microbe, 2016 Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -B but not HLA-C molecules.
Richard Apps +2 more
exaly +5 more sources
Small but Highly Versatile: The Viral Accessory Protein Vpu.
Annual Review of Virology, 2023 Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not generally required for viral replication in cell culture.
M. Volcic, L. Wiesmüller, F. Kirchhoff
semanticscholar +3 more sources
Site-directed mutagenesis of HIV-1 vpu gene demonstrates two clusters of replication-defective mutants with distinct ability to down-modulate cell surface CD4 and tetherin [PDF]
Frontiers in Microbiology, 2010 HIV-1 Vpu acts positively on viral infectivity by mediating CD4 degradation in endoplasmic reticulum and enhances virion release by counteracting a virion release restriction factor, tetherin.
Masako Nomaguchi +4 more
doaj +2 more sources
The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu [PDF]
Retrovirology, 2009 Background The Human Immunodeficiency virus type 1 (HIV-1) Vpu protein enhances virus release from infected cells and induces proteasomal degradation of CD4.
Strebel Klaus +3 more
doaj +4 more sources
The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
doaj +3 more sources
The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis
mBio, 2020 People living with HIV can experience accelerated aging and the development of neurological disorders. Recently, we reported that HIV-1 infection results in a dramatic loss of peroxisomes in macrophages and brain tissue.
Zaikun Xu +4 more
semanticscholar +4 more sources
HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells
Cell Reports, 2016 Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions.
Ferdinand Roesch +2 more
exaly +2 more sources
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
Nature, 2008 Stuart Neil, Paul D Bieniasz
exaly +2 more sources
Anti-tetherin activities in Vpu-expressing primate lentiviruses [PDF]
Retrovirology, 2010 Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells.
Haworth Kevin G +5 more
doaj +3 more sources