Results 21 to 30 of about 8,539 (222)
, 2021 (A) Schematic depicting APEX2 staining protocol for visualization by electron microscopy. (B) HeLa P4.R5 cells were transfected with the codon-optimized Vpu constructs bearing a C-terminal APEX2 tag.
Sumit K. Chanda (11768006) +11 more
core +1 more source
A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.
PLoS ONE, 2015 BackgroundPandemic strains of HIV-1 (group M) encode a total of nine structural (gag, pol, env), regulatory (rev, tat) and accessory (vif, vpr, vpu, nef) genes.
Simon M Langer +7 more
doaj +1 more source
The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
Retrovirology, 2018 Background The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence.
Emily N. Pawlak +4 more
doaj +1 more source
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathogens, 2013 Tetherin (Bst2/CD317/HM1.24) is an interferon-induced antiviral host protein that inhibits the release of many enveloped viruses by tethering virions to the cell surface.
Matthew W McNatt +2 more
doaj +1 more source
PLoS Pathogens, 2007 Viral protein U (Vpu) of HIV-1 has two known functions in replication of the virus: degradation of its cellular receptor CD4 and enhancement of viral particle release.
Emilie Estrabaud +8 more
doaj +1 more source
Virology Journal, 2012 Background Unintegrated HIV-1 DNA serves as transcriptionally active templates in HIV-infected cells. Several host factors including NF-κβ enhance HIV-1 transcription.
Emeagwali Nkiruka, Hildreth James EK
doaj +1 more source
PLoS Pathogens, 2009 Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this
Bastien Mangeat +5 more
doaj +1 more source
PLoS Pathogens, 2014 The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein ...
Suzanne Pickering +5 more
doaj +1 more source
Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors
Frontiers in Virology, 2022 HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have ...
Gisele Umviligihozo +22 more
doaj +1 more source
In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts
Medical Sciences, 2019 Tetherin, an interferon-induced host protein encoded by the bone marrow stromal antigen 2 (BST2/CD317/HM1.24) gene, is involved in obstructing the release of many retroviruses and other enveloped viruses by cross-linking the budding virus particles to ...
Patil Sneha +2 more
doaj +1 more source