Results 1 to 10 of about 3,206 (112)

Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists [PDF]

Viruses, 2023
Coronavirus infection induces interferon-stimulated genes, one of which encodes Tetherin, a transmembrane protein inhibiting the release of various enveloped viruses from infected cells.
Dorota Kmiec, Daniel Sauter, Michael Schindler   +2 more
exaly   +4 more sources

Identification of Two Isoforms of Canine Tetherin in Domestic Dogs and Characterization of Their Antiviral Activity against Canine Influenza Virus

Viruses, 2023
Canine influenza virus (CIV) significantly threatens the canine population and public health. Tetherin, an innate immune factor, plays an important role in the defense against pathogen invasion and has been discovered to restrict the release of various ...
Shaotang Ye, Shoujun Li, Lintao Zhong
exaly   +3 more sources

Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism

Viruses, 2014
The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it from the site of viral budding, the plasma membrane, and this process depends on specific ...
Stefan Pöhlmann, Michael Schindler, Stephan Becker   +2 more
exaly   +3 more sources

Identification of the functional domains of canine tetherin in antiviral activity against canine influenza virus [PDF]

Frontiers in Veterinary Science
Canine influenza virus (CIV) is a respiratory pathogen that causes fever, coughing, and sneezing in dogs and is continuously circulating in canine populations. Tetherin is an antiviral host restriction factor mediated by interferon, capable of inhibiting
Jiajun Ou, Jiajun Ou, Jiajun Ou, Yixin Dai, Yujie Jiang, Lingzhi Dai, Liang Xu, Gang Lu, Gaoming Lou, Shoujun Li   +9 more
doaj   +2 more sources

BST2/Tetherin Inhibition of Alphavirus Exit

Viruses, 2015
Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped ...
Yaw Shin Ooi, Mathieu Dube, Margaret Kielian   +2 more
exaly   +3 more sources

Tetherin antagonism by SARS‐CoV‐2 ORF3a and spike protein enhances virus release [PDF]

EMBO Reports, 2023
Naomi Mcgovern, Jonathan C Brown, James R Edgar   +2 more
exaly   +2 more sources

The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells. [PDF]

PLoS ONE, 2017
Vesicular stomatitis virus (VSV) release from infected cells is inhibited by the interferon (IFN)-inducible antiviral host cell factor tetherin (BST-2, CD317).
Constantin Brinkmann, Markus Hoffmann, Anastasia Lübke, Inga Nehlmeier, Annika Krämer-Kühl, Michael Winkler, Stefan Pöhlmann   +6 more
doaj   +1 more source

Tetherin restricts direct cell-to-cell infection of HIV-1

Retrovirology, 2010
Background Tetherin (BST-2/CD317/HM1.24) is an interferon (IFN)-inducible factor of the innate immune system, recently shown to exert antiviral activity against HIV-1 and other enveloped viruses by tethering nascent viral particles to the cell surface ...
Bar-Magen Tamara, Donahue Daniel A, Sloan Richard D, Kuhl Björn D, Liang Chen, Wainberg Mark A   +5 more
doaj   +1 more source

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.

PLoS ONE, 2012
The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu.
Michael Winkler, Stephanie Bertram, Kerstin Gnirß, Inga Nehlmeier, Ali Gawanbacht, Frank Kirchhoff, Christina Ehrhardt, Stephan Ludwig, Miriam Kiene, Anna-Sophie Moldenhauer, Ulrike Goedecke, Christina B Karsten, Annika Kühl, Stefan Pöhlmann   +13 more
doaj   +1 more source

In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.

PLoS ONE, 2014
The interferon-inducible cellular protein tetherin (CD317/BST-2) inhibits the release of a broad range of enveloped viruses. The HIV-1 accessory protein Vpu enhances virus particle release by counteracting this host restriction factor.
Abdul A Waheed, Nishani D Kuruppu, Kathryn L Felton, Darren D'Souza, Eric O Freed   +4 more
doaj   +1 more source