Results 1 to 10 of about 3,951 (144)

Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists [PDF]

Viruses, 2023
Coronavirus infection induces interferon-stimulated genes, one of which encodes Tetherin, a transmembrane protein inhibiting the release of various enveloped viruses from infected cells.
Elena Hagelauer, Rishikesh Lotke, Dorota Kmiec, Dan Hu, Mirjam Hohner, Sophie Stopper, Rayhane Nchioua, Frank Kirchhoff, Daniel Sauter, Michael Schindler   +9 more
doaj   +3 more sources

Identification of the functional domains of canine tetherin in antiviral activity against canine influenza virus [PDF]

Frontiers in Veterinary Science
Canine influenza virus (CIV) is a respiratory pathogen that causes fever, coughing, and sneezing in dogs and is continuously circulating in canine populations. Tetherin is an antiviral host restriction factor mediated by interferon, capable of inhibiting
Jiajun Ou, Jiajun Ou, Jiajun Ou, Yixin Dai, Yujie Jiang, Lingzhi Dai, Liang Xu, Gang Lu, Gaoming Lou, Shoujun Li   +9 more
doaj   +3 more sources

Glycosylation of canine tetherin is essential for its antiviral activity against H3N2 canine influenza virus [PDF]

Frontiers in Veterinary Science
Tetherin is an interferon-induced-expressing transmembrane protein that utilizes a unique topology to restrict the release of enveloped viruses from the surface of the cell membrane.
Liang Xu, Liang Xu, Yuwen Hou, Yuwen Hou, Shizhe Liu, Shizhe Liu, Yixin Dai, Yixin Dai, Jiajun Ou, Jiajun Ou, Shaotang Ye, Shaotang Ye, Zhen Wang, Zhen Wang, Gang Lu, Gang Lu, Shoujun Li, Shoujun Li   +17 more
doaj   +3 more sources

Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation [PDF]

Infectious Medicine, 2023
s: Background: HIV-1 Vpu acts by counteracting the tethering function of tetherin and resulting in the release of HIV-1 virion. Disrupting Vpu-tetherin interactions may provide a promising new target for antiretroviral therapy.
Shuai Chang, Lifeng Cai, Yongchang Yang, Binlian Sun, Jingyun Li, Jie Liu, Lin Li   +6 more
doaj   +3 more sources

Identification of Two Isoforms of Canine Tetherin in Domestic Dogs and Characterization of Their Antiviral Activity against Canine Influenza Virus

Viruses, 2023
Canine influenza virus (CIV) significantly threatens the canine population and public health. Tetherin, an innate immune factor, plays an important role in the defense against pathogen invasion and has been discovered to restrict the release of various ...
Liang Xu, Jiajun Ou, Xuerui Hu, Yanhong Zheng, Shaotang Ye, Lintao Zhong, Zhiying Lai, Siqi Cai, Gang Lu, Shoujun Li   +9 more
doaj   +2 more sources

Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release. [PDF]

EMBO Rep, 2023
The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon‐induced protein that forms parallel homodimers between the host cell and viral ...
Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR.   +14 more
europepmc   +2 more sources

Exosome Tethering Requires Tetherin Homodimerisation. [PDF]

Biol Cell
Exosomes are small extracellular vesicles that originate as intraluminal vesicles (ILVs) within multivesicular bodies (MVBs). Upon fusion of MVBs with the plasma membrane, ILVs are released into the extracellular environment as exosomes.
Yıldızhan Y, Bourke AM, Jackson HK, Manna PT, Palmulli R, Edgar JR.   +5 more
europepmc   +2 more sources

EIAV encodes an accessory protein that antagonizes the host restriction factor equine tetherin. [PDF]

Proc Natl Acad Sci U S A
Significance Genetically, equine infectious anemia virus (EIAV) has traditionally been considered as one of the simplest lentiviruses. Recently, two viral proteins of EIAV, Mat and Grev, were identified in our laboratory.
Bai B, Zhang X, Zhang M, Ma W, Li J, Zhang H, Na L, Guo X, Lin Y, Wang XF, Wang X.   +10 more
europepmc   +2 more sources

Independent loss events of a functional tetherin gene in galliform birds. [PDF]

J Virol, 2023
The restriction factor tetherin (bone marrow stromal cell antigen 2) is an interferon-inducible protein preventing the release of newly formed viral particles from infected cells.
Krchlíková V, Lotke R, Haußmann I, Reinišová M, Kučerová D, Pecnová Ľ, Ungrová L, Hejnar J, Sauter D, Elleder D.   +9 more
europepmc   +2 more sources

Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein. [PDF]

PLoS Pathog
Human respiratory syncytial virus (RSV) is an enveloped RNA virus and the leading viral agent responsible for severe pediatric respiratory infections worldwide.
Marougka K, Judith D, Jaouen T, Blouquit-Laye S, Cosentino G, Berlioz-Torrent C, Rameix-Welti MA, Sitterlin D.   +7 more
europepmc   +2 more sources