Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis [PDF]
Frontiers in Immunology, 2021 HIV-1 must overcome host antiviral restriction factors for efficient replication. We hypothesized that elevated levels of bone marrow stromal cell antigen 2 (BST-2), a potent host restriction factor that interferes with HIV-1 particle release in some ...
Ravesh Singh +24 more
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Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients [PDF]
Retrovirology, 2022 Background Bone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks the release of HIV-1 virions from infected cells.
Hlelolwenkosi Mlimi +4 more
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BST-2 inhibits SARS-CoV-2 egress at intracellular membranes and is neutralized by ORF7a [PDF]
Scientific ReportsBone marrow stromal antigen 2 (BST-2, or tetherin) is an interferon-inducible host restriction factor that inhibits the release of enveloped viruses by tethering nascent virions to cellular membranes.
Adam Smith, Xinhong Dong
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BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway [PDF]
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry.
Chenchen Zhao +11 more
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The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2 [PDF]
VirusesBone marrow stromal cell antigen 2 (BST-2) is a restriction factor for human immunodeficiency virus type I (HIV-1) and plays an important role in regulating the release of viral particles.
Man-Di Zhang +9 more
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BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. [PDF]
PLoS Pathogens, 2018 The interferon inducible protein, BST-2 (or, tetherin), plays an important role in the innate antiviral defense system by inhibiting the release of many enveloped viruses.
Shuzo Urata +7 more
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Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses [PDF]
mBio, 2019 The HIV-1 accessory protein Vpu enhances viral release by counteracting the restriction factor BST-2. Furthermore, Vpu promotes NK cell evasion by downmodulating cell surface NTB-A and PVR, known ligands of the NK cell receptors NTB-A and DNAM-1 ...
Jérémie Prévost +17 more
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βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin [PDF]
Viruses, 2018 The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein
Yul Eum Song +5 more
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The role of BST-2/Tetherin in host protection and disease manifestation [PDF]
Immunity, Inflammation and Disease, 2016 Chioma M Okeoma, Wadie Mahauad-Fernandez
exaly +2 more sources
Crystals, 2021 Ba0.6Sr0.4TiO3 (BST) ceramic materials have been widely used in the field of multilayer ceramic capacitors. Surface modification through the surface coating to form a heterogeneous layer could effectively improve the dielectric properties.
Zhuo Li +15 more
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