Results 1 to 10 of about 16,707 (156)

Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis [PDF]

Frontiers in Immunology, 2021
HIV-1 must overcome host antiviral restriction factors for efficient replication. We hypothesized that elevated levels of bone marrow stromal cell antigen 2 (BST-2), a potent host restriction factor that interferes with HIV-1 particle release in some ...
Ravesh Singh, Ravesh Singh, Ravesh Singh, Veron Ramsuran, Veron Ramsuran, Veron Ramsuran, Veron Ramsuran, Vivek Naranbhai, Vivek Naranbhai, Vivek Naranbhai, Nonhlanhla Yende-Zuma, Nigel Garrett, Koleka Mlisana, Krista L. Dong, Bruce D. Walker, Bruce D. Walker, Bruce D. Walker, Salim S. Abdool Karim, Mary Carrington, Mary Carrington, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u   +24 more
doaj   +2 more sources

Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients [PDF]

Retrovirology, 2022
Background Bone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks the release of HIV-1 virions from infected cells.
Hlelolwenkosi Mlimi, Kewreshini K. Naidoo, Jenniffer Mabuka, Thumbi Ndung’u, Paradise Madlala   +4 more
doaj   +2 more sources

BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway [PDF]

Microorganisms
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry.
Chenchen Zhao, Yan Qin, Haixin Huang, Yuying Li, Xinyu Zhang, Lin Zhou, Lulu Xie, Yimin Zhou, Yanqing Hu, Wei Chen, Tian Lan, Wen-Chao Sun   +11 more
doaj   +2 more sources

The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2 [PDF]

Viruses
Bone marrow stromal cell antigen 2 (BST-2) is a restriction factor for human immunodeficiency virus type I (HIV-1) and plays an important role in regulating the release of viral particles.
Man-Di Zhang, Fan Chen, Wen-Qiang He, Ying Lu, Feng-Liang Liu, Hong-Guang Zhang, Liu-Meng Yang, Chun-Sheng Dong, Si-Dong Xiong, Yong-Tang Zheng   +9 more
doaj   +2 more sources

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. [PDF]

PLoS Pathogens, 2018
The interferon inducible protein, BST-2 (or, tetherin), plays an important role in the innate antiviral defense system by inhibiting the release of many enveloped viruses.
Shuzo Urata, Elizabeth Kenyon, Debasis Nayak, Beatrice Cubitt, Yohei Kurosaki, Jiro Yasuda, Juan C de la Torre, Dorian B McGavern   +7 more
doaj   +2 more sources

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses [PDF]

mBio, 2019
The HIV-1 accessory protein Vpu enhances viral release by counteracting the restriction factor BST-2. Furthermore, Vpu promotes NK cell evasion by downmodulating cell surface NTB-A and PVR, known ligands of the NK cell receptors NTB-A and DNAM-1 ...
Jérémie Prévost, Suzanne Pickering, Mitchell J. Mumby, Halima Medjahed, Gabrielle Gendron-Lepage, Gloria G. Delgado, Brennan S. Dirk, Jimmy D. Dikeakos, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Frederic Bibollet-Ruche, Beatrice H. Hahn, Mathieu Dubé, Daniel E. Kaufmann, Stuart J. D. Neil, Andrés Finzi, Jonathan Richard   +17 more
doaj   +2 more sources

βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin [PDF]

Viruses, 2018
The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein
Yul Eum Song, Daniel Cyburt, Tiffany M. Lucas, Devon A. Gregory, Terri D. Lyddon, Marc C. Johnson   +5 more
doaj   +2 more sources

The role of BST-2/Tetherin in host protection and disease manifestation. [PDF]

Immun Inflamm Dis, 2016
Mahauad-Fernandez WD, Okeoma CM.
europepmc   +2 more sources

Core-Shell Structure and Dielectric Properties of Ba_0.6Sr_0.4TiO₃@ Fe₂O₃ Ceramics Prepared by Co-Precipitation Method

Crystals, 2021
Ba0.6Sr0.4TiO3 (BST) ceramic materials have been widely used in the field of multilayer ceramic capacitors. Surface modification through the surface coating to form a heterogeneous layer could effectively improve the dielectric properties.
Zhuo Li, Chenbo Wang, Zixuan Wang, Dandan Zhang, Yangxiao Qin, Qiangbin Yang, Zhuo Wang, Peng Zhao, Xinshuai Ma, Minghan Li, Tao Ai, Xin Yan, Yanhui Niu, Biaolin Peng, Shikuan Sun, Dawei Wang   +15 more
doaj   +1 more source

Identification of residues in the BST-2 TM domain important for antagonism by HIV-1 Vpu using a gain-of-function approach

Frontiers in Microbiology, 2011
The HIV-1 Vpu protein enhances the release of viral particles from the cell surface in a cell-type specific manner. In the absence of Vpu, nascent virions remain tethered to the cell surface in restricted cell types. Recently, the human host factor BST-2/
Takeshi eYoshida, Sandra eKao, Klaus eStrebel   +2 more
doaj   +1 more source