Association of BST-2 Gene Variants With HIV Disease Progression Underscores the Role of BST-2 in HIV Type 1 Infection [PDF]
The Journal of Infectious Diseases, 2012 We tested bone marrow stromal cell antigen 2 (BST-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region, and rs10415893, a tag single-nucleotide polymorphism in the 3' untranslated region, for their association with human immunodeficiency virus type 1 (HIV-1) infection and disease progression.
Laplana Lafaja, Marina +4 more
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2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation. [PDF]
Retrovirology, 2016 BST-2 is an interferon-induced host restriction factor that inhibits the release of diverse mammalian enveloped viruses from infected cells by physically trapping the newly formed virions onto the host cell surface. Human Immunodeficiency Virus-1 (HIV-1) encodes an accessory protein Vpu that antagonizes BST-2 by down-regulating BST-2 from the cell ...
Zhang Q +11 more
europepmc +4 more sources
Potential Vorticity Mixing in a Tangled Magnetic Field [PDF]
, 2020 A theory of potential vorticity (PV) mixing in a disordered (tangled) magnetic field is presented. The analysis is in the context of $\beta$-plane MHD, with a special focus on the physics of momentum transport in the stably stratified, quasi-2D solar ...
Chen, Chang-Chun, Diamond, Patrick H
core +2 more sources
Influenza Virus Partially Counteracts Restriction Imposed by Tetherin/BST-2 [PDF]
Journal of Biological Chemistry, 2012 Influenza virus infections lead to a burst of type I interferon (IFN) in the human respiratory tract, which most probably accounts for a rapid control of the virus. Although in mice, IFN-induced Mx1 factor mediates a major part of this response, the situation is less clear in humans.
Mangeat, Bastien +7 more
openaire +3 more sources
Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 [PDF]
, 2013 SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr
A Bergamaschi +47 more
core +7 more sources
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
Sight (un)specific: performance as research predicated upon deploying acts of visual negation [PDF]
, 2017 This paper promotes debate into varying aspects of practice that was produced as part of You Don't Need Eyes To See, You Need Vision, a recent event which presented new work by artists Lee Campbell, Adrian Lee and Carali McCall.
Campbell, Lee +2 more
core +2 more sources
Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea
Heliyon, 2023 Objective: Obesity is a significant risk factor for metabolic syndrome, type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, and cardiovascular disorders.
Chingwen Yu +3 more
doaj +1 more source
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells.
PLoS ONE, 2015 BackgroundBone marrow stromal antigen 2 (BST-2) is a known anti-viral gene that has been recently identified to be overexpressed in many cancers, including breast cancer.
Wadie D Mahauad-Fernandez +3 more
doaj +1 more source
On the striated regularity for the 2D anisotropic Boussinesq system [PDF]
, 2019 In this paper, we investigate the global existence and uniqueness of strong solutions to 2D Boussinesq system with anisotropic thermal diffusion or anisotropic viscosity and with striated initial data.
Paicu, Marius, Zhu, Ning
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