Ebolavirus replication and Tetherin/BST-2 [PDF]
Frontiers in Microbiology, 2012 Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro eYasuda
doaj +6 more sources
The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu [PDF]
Retrovirology, 2009 Background The Human Immunodeficiency virus type 1 (HIV-1) Vpu protein enhances virus release from infected cells and induces proteasomal degradation of CD4.
Strebel Klaus +3 more
doaj +4 more sources
Structural basis for the antiviral activity of BST-2/tetherin and its viral antagonism [PDF]
Frontiers in Microbiology, 2011 The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. eArias +2 more
doaj +3 more sources
The great escape: viral strategies to counter BST-2/tetherin.
PLoS Pathogens, 2010 The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses.
Janet L Douglas +5 more
doaj +4 more sources
Identification and functional analysis of three isoforms of bovine BST-2. [PDF]
PLoS ONE, 2012 Human BST-2 (hBST-2) has been identified as a cellular antiviral factor that blocks the release of various enveloped viruses. Orthologues of BST-2 have been identified in several species, including human, monkeys, pig, mouse, cat and sheep. All have been
Eri Takeda +5 more
doaj +4 more sources
Mechanistic study of BST-2 down-modulation by HIV-1 Vpu [PDF]
Retrovirology, 2009 Background Mammals encode proteins that inhibit viral replication at the cellular level. In turn, certain viruses have evolved genes that can counteract these intrinsic restrictions. Human BST-2 (bone marrow stromal cell antigen 2, also named CD317/HM1.24/tetherin) is recently identified an IFN-induced antiviral protein that blocks release of human ...
Jianyong Zhang +3 more
core +4 more sources
Cloning and characterization of the antiviral activity of feline Tetherin/BST-2.
PLoS ONE, 2011 Human Tetherin/BST-2 has recently been identified as a cellular antiviral factor that blocks the release of various enveloped viruses. In this study, we cloned a cDNA fragment encoding a feline homolog of Tetherin/BST-2 and characterized the protein ...
Aiko Fukuma +4 more
doaj +3 more sources
ATP1B3 cooperates with BST-2 to promote hepatitis B virus restriction. [PDF]
J Med Virol, 2020 AbstractIncreasing evidence indicates ATP1B3, one of the regulatory subunits of Na+/K+‐ATPase, is involved in numerous viral propagations, such as HIV and EV71. However, the function and mechanism of ATP1B3 on hepatitis B virus (HBV) propagation is unknown.
Zheng B +8 more
europepmc +4 more sources
Increased BST-2 expression by HBV infection promotes HBV-associated HCC tumorigenesis. [PDF]
J Gastrointest Oncol, 2021 The majority of hepatocellular carcinoma (HCC) is closely associated with hepatitis B virus (HBV) infection, while the mechanism of HCC induced by HBV is debatable. Bone marrow stromal cell antigen 2 (BST-2), an N-glycoprotein, has been characterized as an oncogenic factor in several types of cancer.
Zhang J +6 more
europepmc +4 more sources
Identification of BST-2/tetherin-induced hepatitis B virus restriction and hepatocyte-specific BST-2 inactivation. [PDF]
Sci Rep, 2015 AbstractBST-2/tetherin is an interferon-inducible antiviral protein that blocks the release of various enveloped viruses, including HIV-1. Hepatitis B virus (HBV), a major cause of liver disease, belongs to the Hepadnaviridae family of enveloped DNA viruses. Whether BST-2 regulates HBV production is largely unknown. In this report, we have demonstrated
Lv M +8 more
europepmc +3 more sources