Results 21 to 30 of about 4,158 (155)

Mechanism of HIV-1 virion entrapment by tetherin.

PLoS Pathogens, 2013
Tetherin, an interferon-inducible membrane protein, inhibits the release of nascent enveloped viral particles from the surface of infected cells. However, the mechanisms underlying virion retention have not yet been fully delineated.
Siddarth Venkatesh, Paul D Bieniasz
doaj   +2 more sources

Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation. [PDF]

J Extracell Vesicles
ABSTRACT For cancer cells to escape from the primary tumour and metastasize, they must degrade and navigate through the extracellular matrix (ECM). The transmembrane protease MT1‐matrix metalloprotease (MMP) plays a key role in localized matrix degradation, and its overexpression promotes cancer invasion.
Palmulli R, Jackson HK, Edgar JR.
europepmc   +2 more sources

ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane. [PDF]

J Extracell Vesicles
ABSTRACT Small extracellular vesicles (SEVs) are involved in diverse functions in normal and pathological situations, including intercellular communication, immunity, metastasis and neurodegeneration. Cell release of SEVs is assumed to occur passively right after multivesicular bodies of the endocytic pathway fuse with the plasma membrane. We show here
Bizingre C, Arellano-Anaya Z, Picard F, Pietri M, Baudry A, Roussel F, Bianchi C, Alleaume-Butaux A, Ardila-Osorio H, Romao M, Lavieu G, Raposo G, Schneider B.   +12 more
europepmc   +2 more sources

Tetherin Is as Tetherin Does [PDF]

, 2009
Tetherin is a cellular restriction factor that inhibits the release of HIV and other enveloped viruses from host cells. A paper from Perez-Caballero et al. (2009) in this issue of Cell clarifies how this factor works.
Spearman, Paul, Hammonds, Jason
core   +1 more source

Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long-Read RNA Sequencing. [PDF]

Immunology
We utilised long‐read Nanopore sequencing to characterise the transcriptome of ferret cell lines stimulated with IFN‐α as well as nasal turbinates from ferrets infected with influenza A virus. We identified novel genes and isoforms and observed elongation of poly(A) tails in the ribosome and Coronavirus Disease‐19 pathways in response to IFN‐α ...
Farrukee R, Chang JJ, Zhang J, Barnes JB, Zhang SX, Tan SM, Reading PC, Coin LJM.   +7 more
europepmc   +2 more sources

Ultra Structural Characterisation of Tetherin - a Protein Capable of Preventing Viral Release from the Plasma Membrane

Viruses, 2010
Tetherin is an antiviral restriction factor made by mammalian cells to protect them from viral infection. It prevents newly formed virus particles from leaving infected cells. Its antiviral mechanism appears to be remarkably uncomplicated.
Ravindra K. Gupta, Greg J. Towers
doaj   +1 more source

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

PLoS Pathogens, 2010
The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface.
Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen   +6 more
doaj   +1 more source

HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway. [PDF]

, 2016
BACKGROUND: HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins.
Liu, Y, Mudan Zhang, Zhang, D, Li, M, Zhang, M, Yalan Liu, Mei Li, Hu, Q, Di Zhang, Qinxue Hu   +9 more
core   +1 more source

Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses.

PLoS ONE, 2009
Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined.
Toshie Sakuma, Akira Sakurai, Jiro Yasuda   +2 more
doaj   +1 more source

Tetherin is an exosomal tether [PDF]

, 2016
Exosomes are extracellular vesicles that are released when endosomes fuse with the plasma membrane. They have been implicated in various functions in both health and disease, including intercellular communication, antigen presentation, prion transmission,
Robinson, Margaret S, Banting, George, George Banting, Paul T Manna, Manna, Paul T, James R Edgar, Shinichi Nishimura, Margaret S Robinson, Edgar, James R, Nishimura, Shinichi   +9 more
core   +2 more sources