HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment [PDF]
Retrovirology, 2010 Background In the absence of the Vpu protein, newly formed HIV-1 particles can remain attached to the surface of human cells due to the action of an interferon-inducible cellular restriction factor, BST-2/tetherin.
Guatelli John C +6 more
doaj +6 more sources
Tetherin is an exosomal tether
eLife, 2016 Exosomes are extracellular vesicles that are released when endosomes fuse with the plasma membrane. They have been implicated in various functions in both health and disease, including intercellular communication, antigen presentation, prion transmission,
J. Edgar +4 more
semanticscholar +7 more sources
Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a
bioRxiv, 2023 SARS-CoV-2 infection induces interferon-stimulated genes, one of which encodes Tetherin, a transmembrane protein inhibiting the release of various enveloped viruses from infected cells.
Hagelauer E +10 more
europepmc +2 more sources
Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission
Cell Host and Microbe, 2019 Tetherin is a host defense that physically prevents escape of virions from the plasma membrane. Human tetherin lacks the motif DIWK antagonized by SIV, the antecedent of HIV. Here, we reconstituted the AP-2 clathrin adaptor complex with a simian tetherin
Dorota Kmiec +2 more
exaly +2 more sources
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.
PLoS Pathogens, 2009 Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host-cell factor that interferes with the detachment of virus particles from infected cells.
Bin Jia +8 more
doaj +2 more sources
Anti-tetherin activities in Vpu-expressing primate lentiviruses [PDF]
Retrovirology, 2010 Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells.
Haworth Kevin G +5 more
doaj +3 more sources
Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Microvesicles are cell membrane–derived vesicles that have been shown to augment inflammation. Specifically, monocyte‐derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus formation and ...
Emily A. Weber +7 more
doaj +2 more sources
BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
PLoS Pathogens, 2009 Host cell factors can either positively or negatively regulate the assembly and egress of HIV-1 particles from infected cells. Recent reports have identified a previously uncharacterized transmembrane protein, tetherin/CD317/BST-2, as a crucial host ...
Kei Miyakawa +7 more
doaj +3 more sources
The Nef Protein of the Macrophage Tropic HIV-1 Strain AD8 Counteracts Human BST-2/Tetherin
Viruses, 2020 Bone Marrow Stromal Cell Antigen 2 (BST-2)/tetherin inhibits the release of numerous enveloped viruses by physically tethering nascent particles to infected cells during the process of viral budding from the cell surface.
Sebastian Giese +4 more
doaj +2 more sources
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
Nature, 2008 Stuart Neil, Paul D Bieniasz
exaly +2 more sources