Tetherin inhibits prototypic foamy virus release [PDF]
Virology Journal, 2011 Background Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses.
Liang Chen +7 more
doaj +7 more sources
Counteraction of the multifunctional restriction factor tetherin [PDF]
Frontiers in Microbiology, 2014 The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1.24) has emerged as a key component of the antiviral immune response.
Daniel eSauter
doaj +5 more sources
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. [PDF]
PLoS Pathogens, 2013 Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells ...
Ruth Serra-Moreno +3 more
doaj +21 more sources
BST2/Tetherin Inhibition of Alphavirus Exit [PDF]
Viruses, 2015 Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped ...
Yaw Shin Ooi +2 more
doaj +5 more sources
Tetherin restricts direct cell-to-cell infection of HIV-1 [PDF]
Retrovirology, 2010 Background Tetherin (BST-2/CD317/HM1.24) is an interferon (IFN)-inducible factor of the innate immune system, recently shown to exert antiviral activity against HIV-1 and other enveloped viruses by tethering nascent viral particles to the cell surface ...
Bar-Magen Tamara +5 more
doaj +2 more sources
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. [PDF]
PLoS Pathogens, 2009 Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin. Here, we show that positive
Matthew W McNatt +7 more
doaj +2 more sources
The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells. [PDF]
PLoS ONE, 2017 Vesicular stomatitis virus (VSV) release from infected cells is inhibited by the interferon (IFN)-inducible antiviral host cell factor tetherin (BST-2, CD317).
Constantin Brinkmann +6 more
doaj +2 more sources
Ebolavirus Replication and Tetherin/BST-2 [PDF]
Frontiers in Microbiology, 2012 Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro Yasuda
core +6 more sources
HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway. [PDF]
Virology Journal, 2016 BACKGROUND: HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins.
A Nilsen +49 more
core +4 more sources
Unique Evolution of Antiviral Tetherin in Bats [PDF]
Journal of Virology, 2020 Bats are an important host of various viruses which are deadly to humans and other mammals but do not cause outward signs of illness in bats. Furthering our understanding of the unique features of the immune system of bats will shed light on how they ...
Joshua A. Hayward +12 more
semanticscholar +3 more sources