Exosome Tethering Requires Tetherin Homodimerisation. [PDF]
Biol CellRather than being released from cells, exosomes can be retained at the plasma membrane via the protein tetherin. Here, we demonstrate that exosome tethering requires the formation of tetherin homodimers, and that mutations in tetherin that impair homodimer formation impair exosome tethering.
Yıldızhan Y +5 more
europepmc +8 more sources
The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. [PDF]
PLoS Pathogens, 2010 Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu ...
Claire Pardieu +8 more
doaj +2 more sources
Tetherin inhibits prototypic foamy virus release [PDF]
Virology Journal, 2011 Background Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses.
Liang Chen +7 more
doaj +2 more sources
Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction. [PDF]
PLoS Pathogens, 2011 Virus assembly and interaction with host-cell proteins occur at length scales below the diffraction limit of visible light. Novel super-resolution microscopy techniques achieve nanometer resolution of fluorescently labeled molecules.
Martin Lehmann +6 more
doaj +2 more sources
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. [PDF]
PLoS Pathogens, 2013 Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells ...
Ruth Serra-Moreno +3 more
doaj +2 more sources
Counteraction of the multifunctional restriction factor tetherin [PDF]
Frontiers in Microbiology, 2014 The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1.24) has emerged as a key component of the antiviral immune response.
Daniel eSauter
doaj +2 more sources
Anti-tetherin activities in Vpu-expressing primate lentiviruses [PDF]
Retrovirology, 2010 Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells.
Haworth Kevin G +5 more
doaj +2 more sources
Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein
Viruses, 2018 Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells.
Yun Zheng +8 more
doaj +2 more sources
Tetherin restricts productive HIV-1 cell-to-cell transmission.
PLoS Pathogens, 2010 The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin.
Nicoletta Casartelli +7 more
doaj +2 more sources
Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism
Viruses, 2015 Tetherin is an interferon-induced, intrinsic cellular response factor that blocks release of numerous viruses, including Ebola virus, from infected cells. As with many viruses targeted by host factors, Ebola virus employs a tetherin antagonist, the viral
Nathan H. Vande Burgt +2 more
doaj +2 more sources