Results 31 to 40 of about 7,006 (230)
Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism [PDF]
Viruses, 2015 Tetherin is an interferon-induced, intrinsic cellular response factor that blocks release of numerous viruses, including Ebola virus, from infected cells. As with many viruses targeted by host factors, Ebola virus employs a tetherin antagonist, the viral
Nathan H. Vande Burgt +2 more
doaj +3 more sources
Mechanism of HIV-1 virion entrapment by tetherin.
PLoS Pathogens, 2013 Tetherin, an interferon-inducible membrane protein, inhibits the release of nascent enveloped viral particles from the surface of infected cells. However, the mechanisms underlying virion retention have not yet been fully delineated.
Siddarth Venkatesh, Paul D Bieniasz
doaj +4 more sources
Tetherin restricts productive HIV-1 cell-to-cell transmission.
PLoS Pathogens, 2010 The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin.
Nicoletta Casartelli +7 more
doaj +4 more sources
Molecular evolution of the primate antiviral restriction factor tetherin.
PLoS ONE, 2010 BackgroundTetherin is a recently identified antiviral restriction factor that restricts HIV-1 particle release in the absence of the HIV-1 viral protein U (Vpu). It is reminiscent of APOBEC3G and TRIM5a that also antagonize HIV.
Jun Liu +3 more
doaj +4 more sources
Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation. [PDF]
J Extracell VesiclesABSTRACT For cancer cells to escape from the primary tumour and metastasize, they must degrade and navigate through the extracellular matrix (ECM). The transmembrane protease MT1‐matrix metalloprotease (MMP) plays a key role in localized matrix degradation, and its overexpression promotes cancer invasion.
Palmulli R, Jackson HK, Edgar JR.
europepmc +2 more sources
ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane. [PDF]
J Extracell VesiclesABSTRACT Small extracellular vesicles (SEVs) are involved in diverse functions in normal and pathological situations, including intercellular communication, immunity, metastasis and neurodegeneration. Cell release of SEVs is assumed to occur passively right after multivesicular bodies of the endocytic pathway fuse with the plasma membrane. We show here
Bizingre C +12 more
europepmc +2 more sources
Tetherin Is as Tetherin Does [PDF]
Cell, 2009 Tetherin is a cellular restriction factor that inhibits the release of HIV and other enveloped viruses from host cells. A paper from Perez-Caballero et al. (2009) in this issue of Cell clarifies how this factor works. The authors show that the aptly named tetherin directly tethers viral particles to the plasma membrane.
Hammonds, Jason, Spearman, Paul
openaire +2 more sources
ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway
bioRxiv, 2023 BST2/Tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virus at the cell surface. BST2 also acts as a sensor of HIV-1 budding, establishing a cellular anti-viral state.
Delphine Judith +9 more
semanticscholar +1 more source
Tetherin and Its Viral Antagonists [PDF]
Journal of Neuroimmune Pharmacology, 2011 Restriction factors comprise an important layer of host defense to fight against viral infection. Some restriction factors are constitutively expressed whereas the majority is induced by interferon to elicit innate immunity. In addition to a number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR,
Kuhl, Björn D. +3 more
openaire +2 more sources