Results 31 to 40 of about 4,158 (155)

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

Retrovirology, 2010
Background In the absence of the Vpu protein, newly formed HIV-1 particles can remain attached to the surface of human cells due to the action of an interferon-inducible cellular restriction factor, BST-2/tetherin.
Guatelli John C, Exline Colin M, Oldenburg Jill E, Yang Su, Lopez Lisa A, Hauser Heiko, Cannon Paula M   +6 more
doaj   +1 more source

Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities.

PLoS Pathogens, 2012
Tetherin (BST-2/CD317/HM1.24) is an IFN induced transmembrane protein that restricts release of a broad range of enveloped viruses. Important features required for Tetherin activity and regulation reside within the cytoplasmic domain. Here we demonstrate
Luis J Cocka, Paul Bates
doaj   +1 more source

Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation.

PLoS ONE, 2013
CD317/tetherin (aka BST2 or HM1.24 antigen) is an interferon inducible membrane protein present in regions of the lipid bilayer enriched in sphingolipids and cholesterol (often termed lipid rafts).
Ruth Rollason, Katie Dunstan, Peter G Billcliff, Paul Bishop, Paul Gleeson, Helen Wise, Paul Digard, George Banting   +7 more
doaj   +1 more source

s-Tetherin modulates l-Tetherin-mediated NF-κB induction.

, 2012
293T cells were transiently transfected with an NF-κB luciferase reporter and varying ratios of l- and s-Tetherin expression vectors with the total tetherin expression plasmids amount kept constant.
Paul Bates (134046), Luis J. Cocka (134043)   +1 more
core   +1 more source

Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.

PLoS Pathogens, 2009
Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host-cell factor that interferes with the detachment of virus particles from infected cells.
Bin Jia, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans   +8 more
doaj   +1 more source

Higher cell surface expression of NZW Tetherin compared to B6 Tetherin in vitro.

, 2012
Untagged Tetherin constructs (500 ng) were transfected into 293T cells in triplicate and analyzed after 2 days. (A) Representative flow cytometry histogram profile of B6 versus NZW Tetherin. Higher median fluorescence intensity (MFI) was observed for NZW
Bradley S. Barrett (176100), Kejun Guo (176108), Diana S. Smith (176104), Sam X. Li (176106), Mario L. Santiago (50346), Kim J. Hasenkrug (49025)   +5 more
core   +1 more source

Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation

Infectious Medicine, 2023
s: Background: HIV-1 Vpu acts by counteracting the tethering function of tetherin and resulting in the release of HIV-1 virion. Disrupting Vpu-tetherin interactions may provide a promising new target for antiretroviral therapy.
Shuai Chang, Lifeng Cai, Yongchang Yang, Binlian Sun, Jingyun Li, Jie Liu, Lin Li   +6 more
doaj   +1 more source

B6 Tetherin cell surface expression is dominant over NZW Tetherin in vivo.

, 2012
(A) Cell surface expression of putative B6:NZW heterodimers in vitro. Equimolar transfection of B6 and NZW Tetherin resulted in similar cell surface expression as B6 Tetherin in vitro. (B) FACS gating strategy. Splenocytes from uninfected B6, NZW and (B6×
Bradley S. Barrett (176100), Kejun Guo (176108), Diana S. Smith (176104), Sam X. Li (176106), Mario L. Santiago (50346), Kim J. Hasenkrug (49025)   +5 more
core   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane.

PLoS Pathogens, 2010
Tetherin/BST2 was identified in 2008 as the cellular factor responsible for restricting HIV-1 replication at a very late stage in the lifecycle. Tetherin acts to retain virion particles on the plasma membrane after budding has been completed.
Jason Hammonds, Jaang-Jiun Wang, Hong Yi, Paul Spearman   +3 more
doaj   +1 more source