Emerging Oncogenic and Immunoregulatory Roles of BST2 in Human Cancers [PDF]
BiomedicinesBST2 has emerged as a multifunctional molecule that bridges antiviral defense, membrane architecture, and tumor immunity. Originally characterized as an interferon-inducible restriction factor that tethers virions to the plasma membrane, BST2 is now ...
Chohee Kim, Seoyoon Choi, Jong-Whi Park
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cGAS-STING Pathway-Induced BST2 Enhances HPV-Infected Keratinocyte Proliferation in Condyloma Acuminata [PDF]
BiomedicinesBackground: Condyloma acuminata (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). Abnormal keratinocyte proliferation is a hallmark of CA, but the underlying mechanisms remain unclear. BST2, an interferon-stimulated gene,
Huayu Huang +4 more
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Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1
Frontiers in Cellular and Infection Microbiology, 2022 Bone marrow stromal cell antigen 2 (BST2), also known as CD317, HM1.24, or tetherin, is a type II transmembrane glycoprotein. Its expression is induced by IFN-I, and it initiates host immune responses by directly trapping enveloped HIV-1 particles onto ...
Yifei Zhao +7 more
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Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/Tetherin
ChemistryOpen, 2021 We present in this work a first X‐ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS‐CoV‐2 orf7a proteins as well as with some of their complexes.
Dr. Maria Petrosino +8 more
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DNA hypomethylation modification promotes BST2 expression in cervical cancer by facilitating STAT1 binding to the promoter of BST2 [PDF]
Infectious Agents and CancerCervical cancer (CC) is a common cancer that causes considerable morbidity and mortality, especially in developing countries. Bone marrow stromal cell antigen 2 (BST2) is a transmembrane glycoprotein, and its promoter methylation has been extensively ...
Reziwanguli Wubuli +3 more
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Downregulation of BST2 Rescues Cochlear Nerve Demyelination in Age-Related Hearing Loss via Enhancing Schwann Cell Migration. [PDF]
Aging CellThe illustration indicates that increased BST2 expression in Schwann cells leads to cochlear nerve demyelination, accelerating hearing loss in ARHL. The upregulation of BST2 reduces POU6F1 expression by activating the NF‐κB pathway, which impairs MPZ transcription and Schwann cell migration, ultimately contributing to neural demyelination in ARHL ...
Liu M +8 more
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Pan-Cancer Analysis of BST2 Expression, Prognostic Significance, and Immune Correlations [PDF]
Cancer Management and ResearchYun-Long Zhao,1 Wei Li,1 Shi-Ming Zhang,1 Si-Bo Chen,2 Cheng-Cheng Ren3 1Plastic Surgery Laser Center, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China; 2Department of Plastic Surgery ...
Zhao YL, Li W, Zhang SM, Chen SB, Ren CC
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Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein. [PDF]
PLoS PathogensHuman respiratory syncytial virus (RSV) is an enveloped RNA virus and the leading viral agent responsible for severe pediatric respiratory infections worldwide.
Katherine Marougka +7 more
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Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS [PDF]
Scientific ReportsAlthough the drug therapeutic targets of acute respiratory distress syndrome (ARDS) are still unclear and no specific drugs for ARDS treatment have been found, some breakthroughs have been gradually made in the biological target pathways such as ...
Kaili Li +5 more
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The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes [PDF]
Nature CommunicationsLethal encephalitis caused by rabies virus (RABV) in mammals is known to be associated with the production of several pro-inflammatory cytokines, but the mechanism of such induction remains unclear.
Jie Wang +15 more
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