DNA hypomethylation modification promotes BST2 expression in cervical cancer by facilitating STAT1 binding to the promoter of BST2 [PDF]
Infectious Agents and CancerCervical cancer (CC) is a common cancer that causes considerable morbidity and mortality, especially in developing countries. Bone marrow stromal cell antigen 2 (BST2) is a transmembrane glycoprotein, and its promoter methylation has been extensively ...
Lili Han
exaly +6 more sources
Emerging Oncogenic and Immunoregulatory Roles of BST2 in Human Cancers [PDF]
BiomedicinesBST2 has emerged as a multifunctional molecule that bridges antiviral defense, membrane architecture, and tumor immunity. Originally characterized as an interferon-inducible restriction factor that tethers virions to the plasma membrane, BST2 is now ...
Chohee Kim, Seoyoon Choi, Jong-Whi Park
doaj +6 more sources
cGAS-STING Pathway-Induced BST2 Enhances HPV-Infected Keratinocyte Proliferation in Condyloma Acuminata [PDF]
BiomedicinesBackground: Condyloma acuminata (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). Abnormal keratinocyte proliferation is a hallmark of CA, but the underlying mechanisms remain unclear. BST2, an interferon-stimulated gene,
Huayu Huang +4 more
doaj +3 more sources
Pan-Cancer Analysis of BST2 Expression, Prognostic Significance, and Immune Correlations [PDF]
Cancer Management and ResearchYun-Long Zhao,1 Wei Li,1 Shi-Ming Zhang,1 Si-Bo Chen,2 Cheng-Cheng Ren3 1Plastic Surgery Laser Center, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China; 2Department of Plastic Surgery ...
Zhao YL, Li W, Zhang SM, Chen SB, Ren CC
doaj +4 more sources
Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer. [PDF]
Adv Sci (Weinh)Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Zhang W +17 more
europepmc +2 more sources
Virus Research, 2023 Porcine reproductive and respiratory syndrome virus (PRRSV) has seriously affected the viability of swine industries worldwide, and effective measures to control PRRSV are urgently required. Understanding the mechanisms of action of antiviral proteins is
Fei Gao, Jinfeng Ti
exaly +3 more sources
Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1
Frontiers in Cellular and Infection Microbiology, 2022 Bone marrow stromal cell antigen 2 (BST2), also known as CD317, HM1.24, or tetherin, is a type II transmembrane glycoprotein. Its expression is induced by IFN-I, and it initiates host immune responses by directly trapping enveloped HIV-1 particles onto ...
Ke Zhao
exaly +3 more sources
Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells [PDF]
Nature CommunicationsSenescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression.
Jun Yong Oh +15 more
doaj +2 more sources
Ependymal cell inflammatory activation in response to intracerebral hemorrhage [PDF]
Journal of NeuroinflammationBackground Neuroinflammation is a central pathological process in secondary brain injury following intracerebral hemorrhage (ICH). While inflammatory responses in perihematomal brain tissue have been extensively investigated, the contribution of ...
Jing Liu +20 more
doaj +2 more sources
The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes [PDF]
Nature CommunicationsLethal encephalitis caused by rabies virus (RABV) in mammals is known to be associated with the production of several pro-inflammatory cytokines, but the mechanism of such induction remains unclear.
Jie Wang +15 more
doaj +2 more sources