Results 31 to 40 of about 6,331 (185)
Stimulation of NF-κB Activity by the HIV Restriction Factor BST2 [PDF]
Journal of Virology, 2013 ABSTRACT BST2 (HM1.24; CD317; tetherin) is an interferon-inducible transmembrane protein that restricts the release of several enveloped viruses, including HIV, from infected cells. Before its activity as an antiviral factor was described, BST2 was identified as an inducer of NF-κB activity.
Andrey, Tokarev +5 more
openaire +2 more sources
PLoS ONE, 2016 The molecular mechanisms controlling the differentiation of bone marrow stromal stem cells into osteoblasts remain largely unknown. In this study, we investigated whether bone marrow stromal antigen 2 (BST2) influences differentiation toward the ...
Su-Hyang Yoo +8 more
doaj +1 more source
eLife, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Xiaofei Jia +7 more
doaj +1 more source
BST2 is an immune-related prognostic biomarker for glioma
, 2023 Abstract Background Glioma is the most common brain cancer. Research has indicated that the tumor microenvironment (TME) plays an important role in the proliferation, invasion, and treatment response of tumors. However, the role of TME in glioma remains unclear.
Mingliang He +4 more
openaire +1 more source
Archives of Medical Science, 2019 Introduction Gefitinib, well known as a new antitumor agent, has been applied in various cancers such as oral squamous cell carcinoma (OSCC). However, most patients eventually acquire resistance to gefitinib, and the molecular mechanism of gefitinib ...
Huang Jin +3 more
doaj +1 more source
HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2 [PDF]
Science Advances, 2021 HIV spreading relies on a key component of antiviral immunity that tethers nascent virions to the surface of infected cells.
Balaji Olety +4 more
openaire +3 more sources
Frontiers in Neuroscience, 2022 Neuroinflammation has long been thought to be associated with amyotrophic lateral sclerosis (ALS) development and progression. However, the exact molecular mechanisms of neuroinflammation underlying ALS remain largely unknown.
Xiaojiao Xu +7 more
doaj +1 more source
Bst2 Isoforms: Distribution and Potential Use In Cancer Therapeutics [PDF]
, 2020 Identifying a cancer-specific cellular target is one of the key factors that can pave a “bench to the bedside” path of a target therapy. Bone marrow stromal cell antigen 2 (BST2) is a raft-associated type II transmembrane protein with an unusual topology.
Muhsin, Ahmed
core +1 more source
Cell Adhesion & Migration, 2020 The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2.
Sonam Verma +3 more
doaj +1 more source
Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-κB Activation. [PDF]
PLoS ONE, 2015 BST2 (CD317, tetherin, HM1.24) is an interferon-inducible transmembrane protein which can directly inhibit the release of enveloped virus particles from infected cells, and its anti-viral activity is reported to be related to the specific topological ...
Weiran Wang +10 more
doaj +1 more source