Results 41 to 50 of about 8,611 (185)
HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2 [PDF]
Science Advances, 2021 HIV spreading relies on a key component of antiviral immunity that tethers nascent virions to the surface of infected cells.
Balaji Olety +4 more
openaire +3 more sources
Frontiers in Neuroscience, 2022 Neuroinflammation has long been thought to be associated with amyotrophic lateral sclerosis (ALS) development and progression. However, the exact molecular mechanisms of neuroinflammation underlying ALS remain largely unknown.
Xiaojiao Xu +7 more
doaj +1 more source
Archives of Medical Science, 2019 Introduction Gefitinib, well known as a new antitumor agent, has been applied in various cancers such as oral squamous cell carcinoma (OSCC). However, most patients eventually acquire resistance to gefitinib, and the molecular mechanism of gefitinib ...
Huang Jin +3 more
doaj +1 more source
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]
, 2017 Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host
Grubhoffer, Libor +6 more
core +2 more sources
BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner [PDF]
, 2014 BCA2 (Rabring7, RNF115 or ZNF364) is a RING-finger E3 ubiquitin ligase that was identified as a co-factor in the restriction imposed by tetherin/BST2 on HIV-1.
Nityanandam, Ramya, Serra-Moreno, Ruth
core +8 more sources
BST2 is an immune-related prognostic biomarker for glioma
, 2023 Abstract Background Glioma is the most common brain cancer. Research has indicated that the tumor microenvironment (TME) plays an important role in the proliferation, invasion, and treatment response of tumors. However, the role of TME in glioma remains unclear.
Mingliang He +4 more
openaire +1 more source
The utility of NBS profiling for plant systematics: a first study in tuber-bearing Solanum species [PDF]
, 2008 Systematic relationships are important criteria for researchers and breeders to select materials. We evaluated a novel molecular technique, nucleotide binding site (NBS) profiling, for its potential in phylogeny reconstruction.
Berg, R.G., van den +3 more
core +2 more sources
Cell Adhesion & Migration, 2020 The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2.
Sonam Verma +3 more
doaj +1 more source
The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface [PDF]
Current Biology, 2021 The midbody at the center of the intercellular bridge connecting dividing cells recruits the machinery essential for the final steps of cytokinesis.1-5 Successive abscission on both sides of the midbody generates a free midbody remnant (MBR) that can be inherited and accumulated in many cancer, immortalized, and stem cells, both in culture and in vivo ...
Presle, Adrien +7 more
openaire +3 more sources
Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-κB Activation. [PDF]
PLoS ONE, 2015 BST2 (CD317, tetherin, HM1.24) is an interferon-inducible transmembrane protein which can directly inhibit the release of enveloped virus particles from infected cells, and its anti-viral activity is reported to be related to the specific topological ...
Weiran Wang +10 more
doaj +1 more source