Results 51 to 60 of about 6,331 (185)

Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin.

PLoS Pathogens
BST2/Tetherin is a restriction factor with broad antiviral activity against enveloped viruses, including coronaviruses. Specifically, BST2 traps nascent particles to membrane compartments, preventing their release and spread.
Yuhang Shi, Sydney Simpson, Yuexuan Chen, Haley Aull, Jared Benjamin, Ruth Serra-Moreno   +5 more
doaj   +1 more source

Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells.

PLoS Pathogens, 2015
Plasmacytoid dendritic cells (pDCs) constitute a major source of type-I interferon (IFN-I) production during acute HIV infection. Their activation results primarily from TLR7-mediated sensing of HIV-infected cells.
Mariana G Bego, Édouard Côté, Nick Aschman, Johanne Mercier, Winfried Weissenhorn, Éric A Cohen   +5 more
doaj   +1 more source

Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag

Frontiers in Microbiology, 2020
Human BCA2/RNF115/Rabring7 (hBCA2) is a RING type E3 ubiquitin ligase with the ability of autoubiquitination or promoting protein ubiquitination. It also acts as a host restriction factor has BST2-dependent and BST2-independent antiviral activity to ...
Meng Qu, Weiran Wang, Weiting Li, Jiaming Cao, Xin Zhang, Chu Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Hui Wu, Wei Kong, Wei Kong, Xianghui Yu, Xianghui Yu   +13 more
doaj   +1 more source

BST2 and DIRAS3 Drive Immune Evasion and Tumor Progression in High-Grade Glioma. [PDF]

Int J Mol Sci
High-grade gliomas (HGGs, WHO grades 3–4) are highly aggressive, with a poor prognosis and treatment resistance. Immune evasion may contribute to their progression, but the role of cytotoxic T-lymphocyte immune evasion (CTLE) is not well-validated. This study analyzed the transcriptomic data of 525 patients from TCGA-GBM-HG_U133A.
Liao Z, Wu S, Shi Z, Chen D, Chen J, Zhang H.   +5 more
europepmc   +3 more sources

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations [PDF]

Proceedings of the National Academy of Sciences, 2010
HIV-1 and other enveloped viruses can be restricted by a host cellular protein called BST2/tetherin that prevents release of budded viruses from the cell surface. Mature BST2 contains a small cytosolic region, a predicted transmembrane helix, and an extracellular domain with a C-terminal GPI anchor.
Schubert H. L., Zhai Q., Sandrin V., Eckert D. M., Garcia-Maya M., Saul L., Sundquist W. I., Steiner R., Hill C. P.   +8 more
openaire   +3 more sources

Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell Line

Frontiers in Molecular Biosciences, 2020
SARS-CoV-2, which emerged in Wuhan (China), has become a great worldwide problem in 2020 and has led to more than 1,000,000 deaths worldwide. Many laboratories are searching for ways to fight this pandemic. We studied the action of the cellular antiviral
Alexander A. Dolskiy, Sergei A. Bodnev, Anastasia A. Nazarenko, Anastasia M. Smirnova, Olga G. Pyankova, Anna K. Matveeva, Irina V. Grishchenko, Tatiana V. Tregubchak, Oleg V. Pyankov, Alexander B. Ryzhikov, Elena V. Gavrilova, Rinat A. Maksyutov, Dmitry V. Yudkin   +12 more
doaj   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Restriction genes for retroviruses influence the risk of multiple sclerosis.

PLoS ONE, 2013
We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians.
Bjørn A Nexø, Bettina Hansen, Kari K Nissen, Lisa Gundestrup, Thorkild Terkelsen, Palle Villesen, Shervin Bahrami, Thor Petersen, Finn S Pedersen, Magdalena J Laska   +9 more
doaj   +1 more source