Results 71 to 80 of about 8,611 (185)

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, EarlyView.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. [PDF]

, 2015
BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins.
Ciuffi, A., Gawanbacht, A., Götz, N., Heilmann, J., Hotter, D., Kirchhoff, F., Kluge, S.F., Krapp, C., Mack, K., McLaren, P.J., Munoz, M., Perreaud, J., Pyndiah, N., Rausell, A., Sauter, D., Telenti, A., Thompson, D.   +16 more
core   +2 more sources

Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell Line

Frontiers in Molecular Biosciences, 2020
SARS-CoV-2, which emerged in Wuhan (China), has become a great worldwide problem in 2020 and has led to more than 1,000,000 deaths worldwide. Many laboratories are searching for ways to fight this pandemic. We studied the action of the cellular antiviral
Alexander A. Dolskiy, Sergei A. Bodnev, Anastasia A. Nazarenko, Anastasia M. Smirnova, Olga G. Pyankova, Anna K. Matveeva, Irina V. Grishchenko, Tatiana V. Tregubchak, Oleg V. Pyankov, Alexander B. Ryzhikov, Elena V. Gavrilova, Rinat A. Maksyutov, Dmitry V. Yudkin   +12 more
doaj   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Effect of dietary supplementation with β-hydroxy-β-methylbutyrate on stress parameters in goat kids

Revista Brasileira de Zootecnia, 2020
The objective of this study was to determine the effect of dietary supplementation with β-hydroxy-β-methylbutyric acid (HMB) on live weight loss and selected blood parameters in goat kids after transportation to the slaughterhouse.
Janina Sowińska, Stanisław Milewski, Dorota Witkowska, Katarzyna Ząbek, Jan Miciński, Anna Wójcik, Tomasz Mituniewicz   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Tetherin inhibits prototypic foamy virus release [PDF]

, 2011
Background: Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses. However, the relationship between tetherin and
Chen Liang, Dan Xu, Fengwen Xu, Juan Tan, Ruikang Liu, Wentao Qiao, Yue Li, Yunqi Geng   +7 more
core   +3 more sources

Restriction genes for retroviruses influence the risk of multiple sclerosis.

PLoS ONE, 2013
We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians.
Bjørn A Nexø, Bettina Hansen, Kari K Nissen, Lisa Gundestrup, Thorkild Terkelsen, Palle Villesen, Shervin Bahrami, Thor Petersen, Finn S Pedersen, Magdalena J Laska   +9 more
doaj   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Structural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral Antagonism [PDF]

, 2011
The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. Arias, Yukie Iwabu, Kenzo Tokunaga   +2 more
core   +2 more sources