Results 81 to 90 of about 6,331 (185)

Multiple surfaces of BST2 are required for Spike binding.

(A) Diagram of the architecture of BST2 and BST2 mutants. CT: cytoplasmic tail. TM: transmembrane domain. EC1: extracellular domain region 1. CC: coiled-coil domain. EC2: extracellular domain region 2. GPI: glycosylphosphatidylinositol anchor.
Sydney Simpson (5132285), Ruth Serra-Moreno (66346), Jared Benjamin (11621560), Yuexuan Chen (11424022), Haley Aull (17756318), Yuhang Shi (8491302)   +5 more
core   +1 more source

Infection of THP-1 cells with HCMV is BST2-dependent.

, 2013
A) Surface levels of endogenous BST2 upon treatment of THP-1 cells with PMA for 24 hours (left panel) and immunoblot for total BST2 present upon PMA induction (right panel) .
Mandana Mansouri (340371), Daniel Malouli (340369), Kasinath Viswanathan (132259), Jay A. Nelson (190058), M. Shane Smith (340367), Klaus Früh (106067)   +5 more
core   +1 more source

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1489-1506, August 2026.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

BST2 facilitates HCMV entry into primary human monocytes.

, 2013
A) BST2 expression on adherent monocytes isolated from PBMCs was analyzed by flow cytometry. B) Immunoblot of pp65, BST2 or GAPDH upon treatment of human monocytes with the indicated siRNAs.
Mandana Mansouri (340371), Daniel Malouli (340369), Kasinath Viswanathan (132259), Jay A. Nelson (190058), M. Shane Smith (340367), Klaus Früh (106067)   +5 more
core   +1 more source

Rab7A is required for efficient production of infectious HIV-1.

PLoS Pathogens, 2011
Retroviruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Rab proteins regulate specific steps in intracellular membrane trafficking by recruiting tethering, docking and fusion factors, as well as ...
Marina Caillet, Katy Janvier, Annegret Pelchen-Matthews, Delphine Delcroix-Genête, Grégory Camus, Mark Marsh, Clarisse Berlioz-Torrent   +6 more
doaj   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, Volume 7, Issue 4, August 2026.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2

, 2017
The cellular protein BST2/ Tetherin acts as a major intrinsic antiviral protein that prevents the release of enveloped viruses by trapping nascent viral particles at the surface of infected cells. Viruses have evolved specific strategies to displace BST2
Nicolas Roy, Katy Janvier, Clarisse Berlioz-Torrent, Grégory Pacini   +3 more
core   +1 more source

Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

Asian Pacific Journal of Tropical Medicine
id="st1" To explore which pattern recognition receptors (PRRs) play a key role in the development of hand, foot, and mouth disease (HFMD) by analyzing PRR-associated genes. id="st2" We conducted a comparative analysis of PRR-associated gene expression in
Muqi Wang, Huiling Deng, Yuan Chen, Yikai Wang, Yufeng Zhang, Chenrui Liu, Meng Zhang, Ting Li, Shuangsuo Dang, Yaping Li   +9 more
doaj   +1 more source

Reproducible Molecular Subtypes in Systemic Lupus Erythematosus Are Associated With Disease Activity, Serology, and Distinct Trajectories Over Time

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Systemic lupus erythematosus (SLE) is biologically heterogeneous, motivating development of reproducible molecular subtypes that can track change over time. The aim of this study was to establish a reproducible molecular stratification of SLE across cohorts and platforms and connect the resulting subtypes to clinical activity, serology, and ...
Loqmane Seridi, Eugene Myshkin, Erika Noss, Sheng Gao, Julio Molineros, Carolyn Cuff, Dawn Waterworth, Matthew J. Loza   +7 more
wiley   +1 more source