Results 91 to 100 of about 8,611 (185)

T‐bet Fate Mapping Reveals Gestational Stage‐Specific Transcriptional Adaptation of Decidual NK Cells

American Journal of Reproductive Immunology, Volume 95, Issue 3, March 2026.
ABSTRACT Problem Natural killer (NK) cells are critical regulators of immune balance at the maternal–fetal interface. T‐bet (Tbx21) is a key transcription factor shaping NK cell effector functions, yet its role in decidual NK (dNK) cell adaptation across gestation remains unclear.
Mona A. Mohamed, Yan Li, Andrea K. Wegrzynowicz, Payton N. Lindner, Jessica Vazquez, Gladys E. Lopez, Aleksandar K. Stanic   +6 more
wiley   +1 more source

Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long‐Read RNA Sequencing

Immunology, Volume 177, Issue 2, Page 299-316, February 2026.
We utilised long‐read Nanopore sequencing to characterise the transcriptome of ferret cell lines stimulated with IFN‐α as well as nasal turbinates from ferrets infected with influenza A virus. We identified novel genes and isoforms and observed elongation of poly(A) tails in the ribosome and Coronavirus Disease‐19 pathways in response to IFN‐α ...
Rubaiyea Farrukee, Jessie J.‐Y. Chang, Jianshu Zhang, James B. Barnes, Shu Xin Zhang, Sher Maine Tan, Patrick C. Reading, Lachlan J. M. Coin   +7 more
wiley   +1 more source

Resilience of BST-2/Tetherin structure to single amino acid substitutions [PDF]

PeerJ, 2019
Human tetherin, also known as BST-2 or CD317, is a dimeric, extracellular membrane-bound protein that consists of N and C terminal membrane anchors connected by an extracellular domain.
Ian R. Roy, Camden K. Sutton, Christopher E. Berndsen   +2 more
doaj   +2 more sources

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer

The Journal of Biochemistry, 2020
Abstract Gastric cancer is one of the most common types of carcinoma with a threat to global health. MicroRNA-760 (miR-760) was significantly down-regulated in the primary tumour of patients with advanced gastric cancer. However, the role of miR-760 in gastric cancer is still unclear.
Weiyu Liu, Yan Li, Shuting Feng, Yadi Guan, Yong Cao   +4 more
openaire   +2 more sources

IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

Cell Reports
Summary: Pancreatic ductal adenocarcinoma (PDAC) features an immunosuppressive tumor microenvironment (TME) that resists immunotherapy. Tumor-associated macrophages, abundant in the TME, modulate T cell responses.
Chenlei Zheng, Junli Wang, Yu Zhou, Yi Duan, Rujia Zheng, Yuting Xie, Xiaobao Wei, Jiangchao Wu, Hang Shen, Mao Ye, Bo Kong, Yun-Hua Liu, Pinglong Xu, Qi Zhang, Tingbo Liang   +14 more
doaj   +1 more source

Decoding innate lymphoid cell heterogeneity and plasticity in colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
This schematic outlines the origin, heterogeneity, and plasticity of ILCs in colorectal cancer. Created in BioRender. Yiyi, X. (2026) https://BioRender.com/0kwrvq7. Abstract Background In colorectal cancer (CRC), innate lymphoid cells (ILCs) play a vital role in preserving and modulating immune homeostasis within the intestinal environment.
Shuomin Zhang, Qingfeng Fu, Zhengyang Xu, Sijun Wang, Guoju You, Xiaoyu Su, Xiaotong Yuan, Chao Liu, Chen Liu, Chaojun Zhang, Bing Liu, Yandong Gong   +11 more
wiley   +1 more source

Type I Interferon Regulates the Expression of Long Non-Coding RNAs [PDF]

, 2014
Interferons (IFNs) are key players in the antiviral response. IFN sensing by the cell activates transcription of IFN-stimulated genes (ISGs) able to induce an antiviral state by affecting viral replication and release.
Celia Prior, Dirk Grimm, Elena Carnero, Elizabeth Guruceaga, Kathleen Börner, Marina Barriocanal, Puri Fortes, Victor Segura   +7 more
core   +2 more sources

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

Subject Teacher Training and Teaching in English [PDF]

, 2010
The purpose of this Master s thesis is on one hand to find out how CLIL (Content and Language Integrated Learning) teachers and English teachers perceive English and its use in teaching, and on the other hand, what they consider important in subject ...
Kuoppala, Marjo-Kaisa
core