Mutations accumulated in the Spike of variants of concern afford more efficient antagonism of BST2.
(A) HEK293T-ACE2 cells stably expressing BST2 were transfected with plasmids encoding the Spike gene from each of the indicated variants of concern. BST2 and Spike levels were measured by western blot.
Sydney Simpson (5132285) +5 more
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The Spike protein is the main BST2 antagonist in SARS-CoV-2.
(A) HEK293T-ACE2 cells stably expressing BST2 were transfected with plasmids coding different proteins of SARS-CoV-2 Wuhan. As a negative control, a construct encoding GST was included.
Sydney Simpson (5132285) +5 more
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A versatile "all-in-one" episomal system simplifies genome engineering in diatoms. [PDF]
Plant PhysiolUranga M.
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IRF1 mediates airway epithelial innate memory through priming BRD4- EP300 activity. [PDF]
Front ImmunolXu X, Gearhart RL, Liu MY, Brasier AR.
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Systemic removal of host restriction factors enables rapid, scalable virus production for cell culture-based vaccine development. [PDF]
Front Bioeng BiotechnolXu Z, Jeon J, Oh J, Shin Y, Park SH.
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SARS-CoV-2 Omicron has improved anti-BST2 activity.
(A & B) A549-ACE2 cells stably expressing pQCXIP or pQCXIP-BST2 were infected with SARS-CoV-2 HK or Omicron variants at MOI = 0.1 or 1. Twenty-four hours post-infection, the levels of BST2 and virus proteins were examined by western blot (A), and virion ...
Sydney Simpson (5132285) +5 more
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Bone Marrow Stromal Cell Antigen 2 Promotes Esophageal Squamous Cell Carcinoma Progression by Mediating the Cell-Cell Interaction between Cancer Cells and Cancer-Associated Fibroblasts. [PDF]
Am J PatholTorigoe R +11 more
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Label-free proteomics and single-cell mass cytometry analysis of 5 immune tissues from mice with artesunate administration reveal immunosuppression of artesunate via BST2 and MDSCs. [PDF]
Fundam ResHong R, Wang A, Li Y, Ding X.
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