BST2 Facilitates Activation of Hematopoietic Stem Cells Through ERK Signaling
Experimental HematologyThe proinflammatory cytokine interferon-gamma (IFNγ) is upregulated in a variety of infections and contributes to bone marrow failure through hematopoietic stem cell (HSC) activation and subsequent exhaustion.
Jeong, Youngjae +11 more
core +4 more sources
Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis [PDF]
BMC Cancer, 2009 Background Bone metastases are frequent complications of breast cancer. Recent literature implicates multiple chemokines in the formation of bone metastases in breast cancer.
Zheng Xin +6 more
doaj +2 more sources
Regulation of Interferon-stimulated gene BST2 by a lncRNA transcribed from a shared bidirectional promoter [PDF]
Frontiers in Immunology, 2015 Recent genome-wide studies have revealed the presence of thousands of long non-coding RNAs (lncRNAs), some of which may play critical roles in the cell.
Hiroto eKambara +7 more
doaj +4 more sources
Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS [PDF]
Scientific ReportsAlthough the drug therapeutic targets of acute respiratory distress syndrome (ARDS) are still unclear and no specific drugs for ARDS treatment have been found, some breakthroughs have been gradually made in the biological target pathways such as ...
Kaili Li +5 more
doaj +2 more sources
BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells [PDF]
European Journal of Immunology, 2015 In contrast to peripheral plasmacytoid DCs (pDCs), thymic pDCs constitutively express low levels of IFN-α. This leads to induction of interferon secondary genes (ISGs) in medullary thymocytes, raising the question whether IFN-α may play a role in T-cell ...
Bianca Blom +6 more
core +7 more sources
Frontiers in Immunology, 2015 Many long non-coding RNAs (lncRNAs) are expressed in cells but only a few have been well characterized. In these cases, lncRNAs have been shown to be key regulators of several cellular processes.
Puri Fortes, Víctor Segura
exaly +3 more sources
Uncovering the role of RNA binding proteins in colorectal cancer through single-cell transcriptomic analysis [PDF]
Scientific ReportsColorectal cancer (CRC) is a globally prevalent malignancy associated with high mortality rates. Despite the existence of various treatment modalities, the prognosis for CRC remains relatively poor.
Mengxin Lin +8 more
doaj +2 more sources
Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling [PDF]
Blood Advances, 2021 Abstract The reactivity of platelets, which play a key role in the pathogenesis of atherothrombosis, is tightly regulated. The integral membrane protein tetherin/bone marrow stromal antigen-2 (BST-2) regulates membrane organization, altering both lipid and protein distribution within the plasma membrane.
Xiaojuan Zhao +18 more
openaire +4 more sources
The role of BST2/tetherin in feline retrovirus infection [PDF]
Veterinary Immunology and Immunopathology, 2011 Pathogenic retroviral infections of mammals have induced the evolution of cellular anti-viral restriction factors and have shaped their biological activities. This intrinsic immunity plays an important role in controlling viral replication and imposes a barrier to viral cross-species transmission.
Dietrich, Isabelle +2 more
openaire +3 more sources
BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer
International Journal of Biological Sciences, 2023 Background: Tumor-associated macrophages (TAMs) are one of the most prominent tumor-infiltrating immune cells in the tumor microenvironment (TME) of CRC and play a vital role in the progression of CRC. BST2 was predicted to be associated with the infiltration of TAMs.
He, Xuefeng +9 more
openaire +2 more sources