Results 21 to 30 of about 8,611 (185)

Uncovering the role of RNA binding proteins in colorectal cancer through single-cell transcriptomic analysis [PDF]

Scientific Reports
Colorectal cancer (CRC) is a globally prevalent malignancy associated with high mortality rates. Despite the existence of various treatment modalities, the prognosis for CRC remains relatively poor.
Mengxin Lin, Zongqi Weng, Yuyuan Lin, Jinhong Lai, Meifang Xu, Kangmei Wang, Xianqiang Chen, Hongbin Chen, Jie Pan   +8 more
doaj   +2 more sources

BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway [PDF]

Microorganisms
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry.
Chenchen Zhao, Yan Qin, Haixin Huang, Yuying Li, Xinyu Zhang, Lin Zhou, Lulu Xie, Yimin Zhou, Yanqing Hu, Wei Chen, Tian Lan, Wen-Chao Sun   +11 more
doaj   +2 more sources

BST2 negatively regulates porcine reproductive and respiratory syndrome virus replication by restricting the expression of viral proteins

Virus Research, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV) has seriously affected the viability of swine industries worldwide, and effective measures to control PRRSV are urgently required. Understanding the mechanisms of action of antiviral proteins is
Yujiao Zhang, Ning Kong, Jinfeng Ti, Dongshen Cao, Zhaofeng Sui, Aimin Ge, Liuting Pan, Kuan Zhao, Yanjun Zhou, Guangzhi Tong, Liwei Li, Fei Gao   +11 more
doaj   +1 more source

Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization

Journal of Immunology Research, 2021
Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. Up to now, the detailed function of FGD5-AS1 in cervical cancer and
Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu   +4 more
doaj   +1 more source

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling [PDF]

Blood Advances, 2021
Abstract The reactivity of platelets, which play a key role in the pathogenesis of atherothrombosis, is tightly regulated. The integral membrane protein tetherin/bone marrow stromal antigen-2 (BST-2) regulates membrane organization, altering both lipid and protein distribution within the plasma membrane.
Xiaojuan Zhao, Dominic Alibhai, Ting Sun, Jawad Khalil, James L. Hutchinson, Kaya Olzak, Christopher M. Williams, Yong Li, Richard Sessions, Stephen Cross, Richard Seager, Riyaad Aungraheeta, Alan Leard, Caroline M. McKinnon, David Phillips, Lei Zhang, Alastair W. Poole, George Banting, Stuart J. Mundell   +18 more
openaire   +4 more sources

Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response [PDF]

, 2020
Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a
Artyomov, Maxim, Bambouskova, Monika, Byrum, Andrea K, Collins, Patrick L, Diamond, Michael S, Ma, Hongming, Miner, Jonathan J, Mosammaparast, Nima, Oltz, Eugene M, Porter, Sofia I, Qian, Wei, Zhang, Rong   +11 more
core   +2 more sources

The role of BST2/tetherin in feline retrovirus infection [PDF]

Veterinary Immunology and Immunopathology, 2011
Pathogenic retroviral infections of mammals have induced the evolution of cellular anti-viral restriction factors and have shaped their biological activities. This intrinsic immunity plays an important role in controlling viral replication and imposes a barrier to viral cross-species transmission.
Dietrich, Isabelle, Hosie, Margaret J., Willett, Brian J.   +2 more
openaire   +3 more sources

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium [PDF]

, 2017
Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs)
Abudureyimu, A, Barry, A T, Chauhan, L, Chen, X, Cheng, Z R, Oguejiofor, C F, Wathes, D C   +6 more
core   +1 more source