BST2/Tetherin enhances entry of human cytomegalovirus.
PLoS Pathogens, 2011 Interferon-induced BST2/Tetherin prevents budding of vpu-deficient HIV-1 by tethering mature viral particles to the plasma membrane. BST2 also inhibits release of other enveloped viruses including Ebola virus and Kaposi's sarcoma associated herpesvirus ...
Kasinath Viswanathan +5 more
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Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker
iScience, 2023 Summary: The conjunctival epithelium consists of conjunctival epithelial cells and goblet cells derived from conjunctival epithelial stem/progenitor cells.
Masahiro Kitao +8 more
doaj +3 more sources
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1 [PDF]
eLife, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Xiaofei Jia +7 more
doaj +3 more sources
Vpu and BST2: still not there yet? [PDF]
Frontiers in Microbiology, 2012 Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV-1 replication and are widely accepted as ‘restriction factors’.
Kei eSato +3 more
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BST2/tetherin inhibits dengue virus release from human hepatoma cells.
PLoS ONE, 2012 UnlabelledType I interferons (IFN) have been shown to play an important role for inhibiting Dengue virus (DENV) infection. Identifying IFN-induced cellular proteins are essential for understanding its mechanisms against DENV.
Xiao-Ben Pan +3 more
doaj +3 more sources
Frontiers in Genetics, 2022 Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer.
Yang Kong +19 more
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BST2/Tetherin Inhibition of Alphavirus Exit [PDF]
Viruses, 2015 Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped ...
Yaw Shin Ooi +2 more
doaj +3 more sources
BST2/Tetherin Overexpression Modulates Morbillivirus Glycoprotein Production to Inhibit Cell–Cell Fusion [PDF]
Viruses, 2019 The measles virus (MeV), a member of the genus Morbillivirus, is an established pathogen of humans. A key feature of morbilliviruses is their ability to spread by virus−cell and cell−cell fusion.
James T. Kelly +10 more
doaj +3 more sources
Regulation of Interferon-stimulated gene BST2 by a lncRNA transcribed from a shared bidirectional promoter [PDF]
Frontiers in Immunology, 2015 Recent genome-wide studies have revealed the presence of thousands of long non-coding RNAs (lncRNAs), some of which may play critical roles in the cell.
Hiroto eKambara +7 more
doaj +3 more sources
Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressorsResearch in context [PDF]
EBioMedicine, 2019 Background: A wide range of host restriction factors (RF) become upregulated upon HIV-1 infection to suppress viral infectivity and may aid viremic control in vivo.
Clarissa Van Hecke +8 more
doaj +4 more sources