Results 41 to 50 of about 4,158 (155)

The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis

The FEBS Journal, EarlyView.
H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo, Evodie Peperstraete, Léa Mabille, Joséphine Louvieaux, Jim Marmuse, Clément Lecerf, Chann Lagadec, Xuefen Le Bourhis, Éric Adriaenssens   +8 more
wiley   +1 more source

Tetherin exists as two isoforms.

, 2012
(A) Alignment of the Tetherin amino acid (Black text) and cDNA (Grey text) sequences compared to strong Kozak sequence, M1A and M13I point mutations (highlighted in black).
Paul Bates (134046), Luis J. Cocka (134043)   +1 more
core   +1 more source

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

PLoS Pathogens, 2009
Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet   +5 more
doaj   +1 more source

Quantitative and amino acid sequence analysis of soluble HIV‐1 Vpu and calmodulin interactions

Protein Science, Volume 35, Issue 11, November 2026.
Abstract HIV‐1 Vpu supports viral adaptation through host‐protein interactions. Although mainly membrane‐associated, we recently identified a soluble Vpu form that forms a stable complex with Ca2+‐bound calmodulin (Ca2+–CaM), potentially influencing Vpu trafficking. Here, to determine the binding affinity and identify regions of soluble Vpu involved in
Adeyemi Ogunbowale, Elaheh Hadadianpour, Olamide Ishola, Md Majharul Islam, Natalie Ramos, Arvin Saffarian Delkhosh, Elka R. Georgieva   +6 more
wiley   +1 more source

Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants.

PLoS Pathogens, 2009
Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin. Here, we show that positive
Matthew W McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E Johnson, Stuart J D Neil, Paul D Bieniasz   +7 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.

PLoS Pathogens, 2012
Tetherin is a membrane protein of unusual topology expressed from rodents to humans that accumulates enveloped virus particles on the surface of infected cells.
Bradley S Barrett, Diana S Smith, Sam X Li, Kejun Guo, Kim J Hasenkrug, Mario L Santiago   +5 more
doaj   +1 more source

SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.

PLoS Pathogens, 2011
Lentiviral Nef proteins have multiple functions and are important for viral pathogenesis. Recently, Nef proteins from many simian immunodefiency viruses were shown to antagonize a cellular antiviral protein, named Tetherin, that blocks release of viral ...
Fengwen Zhang, Wilmina N Landford, Melinda Ng, Matthew W McNatt, Paul D Bieniasz, Theodora Hatziioannou   +5 more
doaj   +1 more source

The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola, Md Majharul Islam, Elaheh Hadadianpour, Peter P. Borbat, Adeyemi Ogunbowale, Juan C. R. Amador, Elka R. Georgieva   +6 more
wiley   +1 more source

Ebolavirus replication and Tetherin/BST-2 [PDF]

, 2012
Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro Yasuda, Jiro eYasuda
core   +1 more source