Results 41 to 50 of about 7,006 (230)
The Feline Immunodeficiency Virus Envelope Signal Peptide Is a Tetherin Antagonizing Protein
mBio, 2023 The study of species- and virus-specific differences in restriction factors and their antagonists has been central to deciphering the nature of these key host defenses.
James H Morrison, E. Poeschla
semanticscholar +1 more source
Journal of Virology, 2023 Here, we describe new findings related to the ability of the cytokine IL-27 to regulate the growth of HIV-1 in CD4+ T lymphocytes. IL-27 has long been considered a potent inhibitor of HIV-1 replication, a notion based on several reports showing that this
J. Temerozo +8 more
semanticscholar +1 more source
Cell Reports, 2023 SUMMARY Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV outbreak,
Rodrigo I. Santos +8 more
semanticscholar +1 more source
Journal of Virology, 2023 HIV-1 has obvious host specificity, which has greatly hindered the construction of animal models and severely restricted the development of HIV-1 vaccines and drugs.
Ying Lu +6 more
semanticscholar +1 more source
The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin
The European Physical Journal Plus, 2023 In this paper, we provide evidence that Zn $$^{2+}$$ 2 + ions play a role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2-tetherin host protein.
S. Botticelli +9 more
semanticscholar +1 more source
Tetherin: Holding On and Letting Go [PDF]
Cell, 2010 Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef ...
Sauter, Daniel +2 more
openaire +2 more sources
Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response [PDF]
, 2020 Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a
Artyomov, Maxim +11 more
core +2 more sources
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1
Frontiers in Cellular and Infection Microbiology, 2022 Bone marrow stromal cell antigen 2 (BST2), also known as CD317, HM1.24, or tetherin, is a type II transmembrane glycoprotein. Its expression is induced by IFN-I, and it initiates host immune responses by directly trapping enveloped HIV-1 particles onto ...
Yifei Zhao +3 more
semanticscholar +1 more source